Late-onset and rare far-advanced pulmonary involvement in patients with sarcoidosis in Taiwan

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Chia-Wei HsiehJoung-Liang Lan

Abstract

Sarcoidosis is still considered a rare multisystem disorder in Taiwan, and data on the disease course and outcome are limited. We analyzed the clinical manifestations, disease course and complications in Taiwanese patients with sarcoidosis. A retrospective cohort design was used. Fifty-six patients with sarcoidosis diagnosed between 1985 and 2004 were included. Their clinical features, laboratory findings at initial presentation, disease course, and complications were analyzed. Forty-three patients (76.8%) were female. The mean age at symptom onset was 47 years. The most common clinical symptoms were pulmonary (82.1%), cutaneous (23.2%), ophthalmic (19.6%), and articular (17.8%). Only two patients presented with Löfgren's syndrome. There was a seasonal variation in disease onset, with higher incidence in winter and early spring. No advanced pulmonary involvement was noted. Elevated levels of serum angiotensin converting enzyme (sACE) were found in 72.5% (29/40) of patients with active sarcoidosis, and significantly higher levels of sACE were found in patients with lung involvement (27.98+/-1.71 IU/L vs. 18.2+/-2.76 IU/L; p<0.01). In 50% (20/40) of patients, sACE levels declined significantly in parallel with clinical remission ...Continue Reading

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Citations

Dec 8, 2007·Journal of the Chinese Medical Association : JCMA·Yu-Mei ChungWen-Hu Hsu
Jan 12, 2019·Expert Review of Clinical Immunology·Manuel Ramos-CasalsPilar Brito-Zerón
Aug 9, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fen WangJianping Jia
May 28, 2019·Respiratory Medicine·Manuel Rubio-RivasJuan Mañá

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