Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice

Cellular and Molecular Neurobiology
Preeticia Dkhar, Ramesh Sharma

Abstract

Oxidative stress is an important factor in causing aging and age-related diseases. It is caused by an imbalance between oxidants such as reactive oxygen species (ROS) and antioxidants. Protein oxidation elicited by free radicals may cause protein function disruptions. Protein carbonylation, an irreversible process resulting in loss of function of the modified proteins, is a widely used marker for oxidative stress. In the present study, we have evaluated the levels of protein carbonyls, ROS, and catalase in the cerebral hemispheres of young and aged mice. When aged mice were subjected to a dietary restriction (DR) regimen (alternate days feeding) of 3 months, a significant reduction in the endogenous levels of protein carbonylation as well as ROS and elevation of catalase was observed in their cerebral hemispheres. The present study, thus, demonstrated the antioxidative effects of late-onset DR regimen in the cerebral hemispheres of aged mice which may act as a powerful modulator of age-related neurodegenerative diseases.

References

Sep 1, 1992·Mutation Research·D Harman
Jan 1, 1994·Methods in Enzymology·R L LevineE Shacter
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J ForsterR S Sohal
Feb 1, 1997·Mechanisms of Ageing and Development·C C SpauldingR B Effros
May 15, 1997·The Biochemical Journal·R T DeanM J Davies
Aug 15, 1997·The Journal of Biological Chemistry·B S Berlett, E R Stadtman
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Jul 25, 2000·Methods in Enzymology·E Shacter
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·M L HamiltonA Richardson
Apr 30, 2002·Free Radical Biology & Medicine·M Flint Beal
Jun 28, 2002·Free Radical Biology & Medicine·Pamela A SzwedaLuke I Szweda
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·B J Merry
Sep 5, 2002·Free Radical Biology & Medicine·Rajindar S SohalWilliam C Orr
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenzhen DuanMark P Mattson
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Isabella Dalle-DonneRoberto Colombo
Jun 11, 2004·Biogerontology·Debipreeta Dutta, Ramesh Sharma
Dec 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Navin MaswoodDonald K Ingram
May 7, 2005·Free Radical Research·Shruti AgarwalNilanjan Roy
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
May 14, 2005·Antioxidants & Redox Signaling·Kenneth Hensley, Robert A Floyd
Jan 28, 2006·Life Sciences·You Jung KimGabriel Fernandes
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·G López-LluchR de Cabo
Aug 29, 2006·Free Radical Biology & Medicine·Janet W RankinKorinn E Saker
Sep 27, 2006·Trends in Neurosciences·Mark P Mattson, Aiwu Cheng
Apr 27, 2007·Annals of the New York Academy of Sciences·Sataro GotoRamesh Sharma
May 23, 2007·Aging Cell·Wulf Dröge, Hyman M Schipper
Oct 30, 2007·Ageing Research Reviews·Suresh I S Rattan
Dec 29, 2007·Ageing Research Reviews·Mark P Mattson
Apr 21, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Preeticia Dkhar, Ramesh Sharma
Jan 11, 2011·Trends in Pharmacological Sciences·Barry Halliwell
Dec 21, 2011·Mechanisms of Ageing and Development·Xiao-Dong LiRajindar S Sohal
May 25, 2012·Annals of Nutrition & Metabolism·Laura A Da CostaAhmed El-Sohemy

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Citations

Jun 26, 2014·Journal of Veterinary Science·Mengyun LiLei An
Oct 9, 2016·Cellular and Molecular Neurobiology·Ibanylla Kynjai Hynniewta Hadem, Ramesh Sharma
Jun 9, 2021·Expert Review of Proteomics·Mariona JovéReinald Pamplona

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