Late-onset erythromelalgia in a previously healthy young woman: a case report and review of the literature.

Journal of Medical Case Reports
Shobhana Gaur, Thomas Koroscil

Abstract

Erythromelalgia is a rare disorder characterized by episodic erythema and burning pain, which commonly involves the extremities. We present a case of late onset erythromelalgia in a previously healthy young woman and briefly review the literature. Our patient's case also has additional uncommon features not reported previously. A 33-year-old previously healthy Caucasian woman presented with complaints of episodic burning pain and flushing occurring in a central distribution involving her face, ears, upper chest and, occasionally, her upper extremities. Her symptoms were triggered by lying down or warm temperature exposure and were relieved by cooling measures. Extensive diagnostic work-up looking for secondary causes for the symptoms was negative and the diagnosis of erythromelalgia was made based on details provided in her clinical history supported by raised temperature in the affected area measured by thermography during a symptomatic episode. The patient did not respond to pharmacological therapy or surgical sympathectomy. She was advised on lifestyle modification to avoid activities which triggered her symptoms. She was hypothermic with a core temperature between 92 and 95 degrees F. She also had premature ovarian failure,...Continue Reading

References

Apr 1, 1979·The Journal of Pediatrics·S OzsoyluA Gökalp
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J J Toledo-AralG Mandel
Dec 31, 1996·Brain Research. Molecular Brain Research·J A BlackS G Waxman
Mar 21, 2000·Archives of Dermatology·M D DavisT W Rooke
Mar 21, 2000·Archives of Dermatology·C Mørk, K Kvernebo
Mar 25, 2000·The Journal of Investigative Dermatology·C MorkK Kvernebo
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Theodore R CumminsStephen G Waxman
Jun 17, 2005·Brain : a Journal of Neurology·S D Dib-HajjS G Waxman
Oct 24, 2007·Trends in Neurosciences·Sulayman D Dib-HajjStephen G Waxman
Dec 7, 2007·The Journal of Clinical Investigation·Joost P H Drenth, Stephen G Waxman

❮ Previous
Next ❯

Citations

Jan 1, 2013·Case Reports in Dermatology·Aya KakizakiSetsuya Aiba
Sep 26, 2012·Case Reports in Pediatrics·Kelly GrandyPaul Hong
Jul 31, 2012·Case Reports in Medicine·Fatima KhalidSyed Amer
Jul 1, 2015·Surgical Endoscopy·Moshe HashmonaiChristoph H Schick
Dec 14, 2011·Journal of Child Neurology·Shadé MoodyMary Kay Koenig
Nov 3, 2017·Pediatrics in Review·Dustin E Fleck, Mark F Hoeltzel
Jan 5, 2019·Clinical and Experimental Dermatology·N MannR Murphy
Dec 1, 2018·Annals of Dermatology·Si Hyub LeeJeonghyun Shin

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
amputation

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.