Late onset hyponatremia in preterm newborns: is the sodium content of human milk fortifier insufficient?

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
İsmail Kursad Gokçe, Serife Suna Oguz

Abstract

Introduction: In this study, we aimed to define the incidence and time to detection of late onset hyponatremia (LOH) as well as factors affecting its development in preterm newborns. We also aimed to determine the daily sodium requirement of these patients.Methods: We studied a total of 145 very low birth weight infants with a full or nearly full enteral diet and followed them up until discharge. We recorded demographic and clinic characteristics. We measured serum sodium (SNa) levels at least once a week after the second week. We compared infants with LOH with other infants to analyze possible risk factors.Results: Twenty-nine (20%) infants developed LOH in an average of 23.4 ± 7.8 days. The mean SNa level of these infants was 124.6 ± 5.6 mmol/L. Logistic regression analysis showed that a birth weight of less than 1000 g, preterm early membrane rupture, and nutrition with fortified human milk alone were risk factors for LOH. The mean daily amount of sodium added to the nutrition of hyponatremic preterm infants was 3.6 ± 2.1 mmol/L. Subgroup analysis showed that the incidence of LOH was two times higher (39.2%) in infants with a birth weight of less than 1000 g.Conclusion: We observed the development of LOH within three to four...Continue Reading

References

Jul 1, 1976·Acta paediatrica Scandinavica·S R Siegel, W Oh
Dec 1, 1990·Clinical Pediatrics·S J Wassner, H E Kulin
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Jul 1, 1982·Archives of Disease in Childhood·W W Koo, J M Gupta
Oct 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J RoseW W Koo
Sep 1, 1996·Journal of the American Dietetic Association·L L KloiberR S Hassanein
Feb 8, 1997·BMJ : British Medical Journal·D J MurphyA Johnson
Feb 27, 2001·Biology of the Neonate·T ErtlE Sulyok
Mar 8, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·J Al-DahhanG B Haycock
Jan 21, 2012·Early Human Development·Mario De Curtis, Jacques Rigo
May 23, 2012·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Roseline GalipeauMiguel Chagnon
Mar 28, 2013·Journal of Pregnancy·Robert GalinskyTimothy J M Moss
Nov 16, 2013·World Journal of Pediatrics : WJP·Fatih BolatAsiye Nuhoglu
Apr 2, 2015·Journal of Korean Medical Science·Yoon-Joo KimJung-Hwan Choi

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Citations

Sep 22, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Ji Sook ParkChan-Hoo Park

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