Late-onset neutropenia after RITUXIMAB therapy for multiple sclerosis, neuromyelitis optica spectrum disorders and MOG-antibody-associated diseases.

Multiple Sclerosis and Related Disorders
J RigalDamien Biotti

Abstract

Few cases of late onset neutropenia after RITUXIMAB treatment (LONART) have been reported in patients with neuroinflammatory disorders. We conducted a retrospective analysis of patients treated with RITUXIMAB for neuromyelitis optica spectrum disorders (NMOSD), MOG-antibody-associated disease (MOGAD) and multiple sclerosis (MS) at the Toulouse University Hospital from November 2007 to October 2019. Ten patients with LONART were identified in a total of 385 patients: 4/25 were MOGAD patients, 2/20 were NMOSD patients and only 4/340 were MS patients (p < 0,05). Six required intravenous antibiotics whereas four were asymptomatic. Eight patients received new infusions of RITUXIMAB after resolution of their neutropenia. Neutropenia recurred in one patient.

References

Apr 17, 2015·Multiple Sclerosis and Related Disorders·Annika PlateTania Kümpfel
Dec 19, 2017·Multiple Sclerosis and Related Disorders·Eero RissanenLaura Airas
May 3, 2019·The New England Journal of Medicine·Sean J PittockDean M Wingerchuk

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Citations

Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KuertenLawrence Steinman
Jan 9, 2021·Journal of Neurology·Clara Grazia ChisariFrancesco Patti
Oct 16, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael ZhongVilija Jokubaitis
Mar 31, 2021·Current Opinion in Neurology·Finn Sellebjerg, Martin S Weber
Jun 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mariano MarrodanJorge Correale

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