Late-onset retinoblastoma in a well-functioning fellow eye

Ophthalmology
Paulus T V M de JongGregorius P M Luyten

Abstract

To describe the documented growth, clinical course, and histopathology of retinoblastomas in an untreated and otherwise normal right eye of a 27-year-old white male with a g.153211T>A (p.Tyr606X) mutation in the retinoblastoma 1 gene, whose left eye was enucleated at age 2 years for 2 retinoblastomas. Retrospective interventional case report. Over the years, the right eye was irradiated twice and underwent trans-pars plana vitrectomy, transscleral cryocoagulation, argon laser photocoagulation of tumors and their feeder vessels, extracapsular cataract extraction with posterior chamber lens implantation, and neodymium:yttrium-aluminum-garnet laser treatment of after-cataract in the form of Elschnig's pearls. Finally, the patient received combination chemotherapy with etoposide, methotrexate, actinomycin D, cisplatin, and vincristine. The eye finally had to be removed 12 years later due to tumor recurrences and seeding, pseudohypopyon, and elevated intraocular pressure. Histopathology showed microcellular retinoblastoma cells in the anterior chamber angle and trabecular meshwork without subconjunctival extension and in the nasal ciliary body, pars plana, internal limiting membrane, and optic nerve head anterior to the cribriform p...Continue Reading

References

Sep 3, 1977·Lancet·J S Berkeley, B C Kalita
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z OnadimJ K Cowell
Dec 1, 1990·Archives of Ophthalmology·H L BrooksJ Fontanesi
Feb 1, 1990·Archives of Ophthalmology·J A ShieldsM E Giblin
Jan 1, 1990·Eye·W M Amoaku, D B Archer
Aug 1, 1988·Archives of Ophthalmology·E I TraboulsiH J Manz
May 15, 1988·American Journal of Ophthalmology·J L KinyounC G Wells
Apr 1, 1988·The British Journal of Radiology·G DeanR Maximilien
Feb 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J SchipperH A van Peperzeel
May 1, 1966·American Journal of Ophthalmology·W B Clark
Oct 1, 1983·Archives of Ophthalmology·D H Abramson
Feb 1, 1983·Ophthalmology·T TakahashiT Sashikata
Feb 1, 1995·The British Journal of Ophthalmology·J L KinyounA M Arnold
Feb 17, 2000·Archives of Ophthalmology·A D SinghR C Eagle
Sep 1, 1961·American Journal of Ophthalmology·K S MEHRA, S HAMID
Mar 1, 1963·Archives of Ophthalmology·T A MAKLEY
Jun 1, 1943·The British Journal of Ophthalmology·W B McCrea

❮ Previous
Next ❯

Citations

Sep 1, 2006·Photomedicine and Laser Surgery
May 6, 2014·Journal français d'ophtalmologie·A ChebbiL Nacef
Dec 22, 2007·Seminars in Ophthalmology·Yannek I LeidermanShizuo Mukai
Sep 7, 2012·Ophthalmic Genetics·Vikas KhetanLingam Gopal
Mar 11, 2015·Journal of Pediatric Hematology/oncology·Jung Yoon ChoiHee Young Shin
Jan 1, 2011·Retinal Cases & Brief Reports·Jill R WellsHans E Grossniklaus

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Oman Journal of Ophthalmology
Sunil Kumar SinghAkshay Chandra Deka
Klinische Monatsblätter für Augenheilkunde
S Sporny, M Pruszczynski
Arquivos brasileiros de oftalmologia
João Pessoa de Souza FilhoClélia Maria Erwenne
Journal of Pediatric Ophthalmology and Strabismus
Y MasuyamaA Sawada
© 2022 Meta ULC. All rights reserved