Late Onset Streptococcus agalactiae Meningitis following Early Onset Septicemia: A Preventable Disease?

Case Reports in Pediatrics
Kam Lun HonAlexander K C Leung

Abstract

We report a neonate who presented with early onset Streptococcus agalactiae or group B streptococcus (GBS) septicemia within 24 hours of birth. After discharge at day 14, she went on to develop late onset GBS meningitis at 36 days of age. The infant was treated with intravenous antibiotics on both occasions and eventually discharged home with no apparent sequelae. We address issues associated with GBS infection in infancy including the demographics, risk factors, and the risk of late onset GBS meningitis following an early onset GBS infection. The major source of GBS in early onset GBS disease is maternal birth canal GBS colonization. On the other hand, nosocomial cross-infection is an important source of GBS in late onset disease. Penicillin remains the current treatment of choice for GBS infection. Given the rapid onset and progression within hours of birth and lack of an effective solution for preventing late onset GBS, administration of an effective GBS vaccine in pregnancy could provide a sensible and cost-effective solution in all settings.

References

Sep 1, 1986·Asia-Oceania Journal of Obstetrics and Gynaecology·S H ChanS T Liang
Jul 11, 2003·The Journal of Infectious Diseases·Feng-Ying C LinKaren Adams
Mar 9, 2004·Journal of Clinical Microbiology·Judith S HeelanAlexander J McAdam
Nov 8, 2008·The Pediatric Infectious Disease Journal·Hannah T JordanUNKNOWN Active Bacterial Core Surveillance (ABCs)/Emerging Infections Program Network, CDC
Jun 6, 2009·Italian Journal of Pediatrics·Kam-Lun HonKam-Lau Cheung
Jan 9, 2013·Pediatrics·Alberto BerardiUNKNOWN GBS Prevention Working Group, Emilia-Romagna
Nov 7, 2013·International Journal of Women's Health·Hanan M Al-KadriHani M Tamim
Jan 11, 2014·The Clinical Respiratory Journal·Kam-Lun E HonMargaret Ip
Jul 30, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M Todorova-ChristovaA Dobreva
Aug 20, 2015·Therapeutic Advances in Vaccines·Annalisa NuccitelliDomenico Maione

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.