Late outcomes of drug-eluting versus bare metal stents in saphenous vein grafts: Propensity score analysis

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Robert J ApplegateWilliam Little

Abstract

To compare late outcomes with the routine use of drug-eluting stents (DES) compared with bare-metal stents (BMS) during percutaneous intervention (PCI) of saphenous vein grafts (SVGs). Safety concerns >1 year from stent implantation have been raised about DES used for PCI of SVGs in a small randomized clinical trial. However, there are few studies comparing late outcomes of DES and BMS in routine clinical practice. Clinical outcomes (nonfatal MI, cardiac mortality) were assessed in 74 consecutive patients who received BMS and 74 consecutive propensity score matched patients that received DES for PCI of SVGs. Clinical follow-up was censored at 2 years +/- 30 days for both stent groups. At 2 years, the hazard ratio for DES compared with BMS for PCI of SVGs for target vessel revascularization was 0.54 (0.21-1.36), nonfatal MI or cardiac death was 0.68 (0.27-1.68), cardiac mortality 1.19 (0.32-4.45), and stent thrombosis 0.49 (0.09-2.66). Similar outcomes were observed stratified by propensity score quintile. The routine clinical use of DES for PCI of SVGs was associated with a safety profile that was similar to that of bare metal stents with a clear trend toward a less frequent need for reinterventions.

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Citations

Oct 5, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Luca TestaFrancesco Bedogni
Feb 10, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Emmanouil S BrilakisSubhash Banerjee
Jun 15, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Angel Sanchez-RecaldeJose L Lopez-Sendon
Feb 19, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Satheesh NairMamas A Mamas
Jun 19, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·William B Hillegass
Mar 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paul H TolericoUNKNOWN EVENT Investigators
Feb 18, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Abdul HakeemImran Arif
Mar 17, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Vincenzo PasceriPasquale Lisanti
Feb 2, 2011·Journal of Interventional Cardiology·Mamas A MamasFarzin Fath-Ordoubadi
Aug 14, 2012·Journal of Interventional Cardiology·Fabrizio D'AscenzoImad Sheiban
Dec 15, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Luiz F YbarraExpedito E Ribeiro
Dec 7, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mikkel HougaardLisette Okkels Jensen
Sep 29, 2009·American Heart Journal·Mehdi H ShishehborSamir R Kapadia
Nov 21, 2009·JACC. Cardiovascular Interventions·John S Douglas
Feb 16, 2010·American Heart Journal·Dominique JoyalMark J Eisenberg
Sep 10, 2010·Journal of the American College of Cardiology·Scot Garg, Patrick W Serruys
Nov 26, 2010·Circulation. Cardiovascular Interventions·Jean-Michel ParadisStéphane Rinfret
May 6, 2010·Circulation. Cardiovascular Interventions·Azeem LatibAntonio Colombo

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