PMID: 2507741Nov 1, 1989Paper

Late-phase accumulation of inositol phosphates stimulated by prostaglandins D2 and F2 alpha in neuroblastoma x glioma hybrid NG108-15 cells

Journal of Neurochemistry
M HatanakaO Hayaishi

Abstract

The accumulation of inositol phosphates (IPs) in response to prostaglandins (PGs) was studied in NG108-15 cells preincubated with myo-[3H]inositol. As a positive control, bradykinin caused accumulation of IPs transiently at an early phase (within 1 min) and continuously during a late phase (15-60 min) of incubation in the cells. PGD2 and PGF2 alpha did not significantly cause the accumulation of IPs at an early phase but significantly stimulated inositol bisphosphate (IP2) and inositol monophosphate (IP) formation at late phase of incubation. The maximum stimulation was obtained at greater than 10(-7) M concentrations of these PGs, the levels being three-and twofold for IP2 and IP1, respectively. 9 alpha, 11 beta-PGF2 has a slight effect but PGE2 and the metabolites of PGD2 and PGF2 alpha have no effect up to 10(-6)M. The effects of PGD2 and PGF2 alpha were not additive, but the effect of each PG was additive to that of bradykinin at a late phase of incubation. Inositol 1-monophosphate was mainly identified in the stimulation by 10(-5) M PGD2 and 10(-5) M PGF2 alpha, whereas both inositol 1-monophosphate and inositol 4-monophosphate were produced in the stimulation by 10(5) M bradykinin. Depletion of extracellular Ca2+ diminish...Continue Reading

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A S Milton
Oct 1, 1988·Trends in Neurosciences·S R Nahorski
Jan 1, 1988·The Biochemical Journal·L R StephensP C Downes
Apr 1, 1987·Journal of Neurochemistry·S K Fisher, B W Agranoff
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J S DavisL A West
Mar 22, 1988·Brain Research·H MatsumuraO Hayaishi
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H OnoeO Hayaishi
Jan 30, 1987·Biochemical and Biophysical Research Communications·P MeneM J Dunn
Jan 1, 1974·Analytical Biochemistry·B Hamprecht, T Amano
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R UenoO Hayaishi

❮ Previous
Next ❯

Citations

Dec 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·H Elgendy, R E Hausman
Aug 15, 1991·Biochemical and Biophysical Research Communications·J KitanakaA Baba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
F SquadritoA P Caputi
Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
R E HausmanF Craft
Biochemical and Biophysical Research Communications
H Morii, Y Watanabe
© 2022 Meta ULC. All rights reserved