PMID: 6693667Jan 1, 1984Paper

Late-phase reactions in ocular anaphylaxis in the rat

The Journal of Allergy and Clinical Immunology
M R AllansmithK J Bloch

Abstract

We assessed whether anaphylactic stimulation of rat ocular tissue produces a late-phase reaction at the histologic level. Clinical changes of swelling and redness started within minutes, peaked at about 20 min, and then subsided. Neutrophils increased at 1/2 hr after stimulation, peaked at 6 hr, and subsided to normal at 24 hr. Eosinophils reached a significant increase at 6 hr. Compaction of vessel contents was present at 1/2 hr; vessels were normal thereafter. Extravasated red blood cells and debris in the tissue were prominent at 6 hr. Macrophages had accumulated significantly at 6 hr and maintained that level at 24 hr. Any effect of anaphylaxis on macrophage accumulation was masked because control-injected ocular tissue also showed an accumulation of macrophages at 24 hr. Our results demonstrate that in ocular tissue, as in skin, the early acute phase of immediate hypersensitivity is but one stage of a multiphasic reaction.

References

Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter

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Citations

Jan 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E KhosraviC Hariton
Jun 7, 2003·Current Allergy and Asthma Reports·Margarita CalongeMichael E Stern
Jun 1, 1985·Experimental Eye Research·M R AllansmithK J Bloch
Jul 15, 1985·American Journal of Ophthalmology·J V GreinerM R Allansmith
Mar 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Schoeneich, A R Pécoud
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·P Zuber, A Pécoud
Jul 1, 1993·Survey of Ophthalmology·M B Abelson, K Schaefer
Mar 1, 1986·Experimental Eye Research·S D TrocméM R Allansmith
Jul 1, 1990·The Journal of Allergy and Clinical Immunology·S BoniniF Balsano
Jun 6, 2006·Allergologia et immunopathologia·A AlonsoR Brunzini
Dec 1, 1987·Immunological Investigations·R M NaclerioD Proud
May 1, 1987·Current Eye Research·S BoniniM R Allansmith
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
May 1, 1988·Current Eye Research·S D TrocméM R Allansmith

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