PMID: 9655215Jul 9, 1998Paper

Late phase response in nasal mucosa closely correlated with immediate phase reaction and hyperreactivity to histamine

Acta Oto-laryngologica
N TeradaK Togawa

Abstract

It has been suggested that the onset of the late phase response (LPR) and hyperreactivity to non-specific stimuli occurs in the lower airway. However, its relationship in the nose has not yet been studied. This study was designed to examine the mechanism of LPR and the relationship between LPR and hyperreactivity. A total of 25 Japanese cedar pollinosis patients participated in this study. On the first visit, the frequency of sneezes, weight of nasal discharge, and the nasal airway resistance (NAR) were time-dependently measured without antigen challenge. The histamine reactivity was observed after 12 h. The same protocol was used during the second to fourth visits. The frequency of sneezes, weight of nasal discharge, and NAR were measured continuously for 12 h after antigen challenge, and nasal reactivity to histamine was observed. The percent change of NAR during immediate phase response (IR) and during LPR showed a significant correlation. The frequency of sneezes and weight of nasal discharge induced by histamine were both significantly higher in the positive than in the negative LPR group. These results suggest that the chemical mediators and inflammatory cells inducing nasal swelling during IR cause, directly or indirectl...Continue Reading

References

Sep 1, 1979·The Journal of Allergy and Clinical Immunology·M J Schumacher, M C Pain
Aug 1, 1992·The Journal of Allergy and Clinical Immunology·N TeradaK Togawa
Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Mar 1, 1984·The Journal of Allergy and Clinical Immunology·J E DvoracekG J Gleich

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Citations

Apr 29, 2010·Current Allergy and Asthma Reports·Akiyoshi Konno
Aug 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J PatouC Bachert

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