Late recurrence and progression in non-muscle-invasive bladder cancers after 5-year tumor-free periods

Urology
Kazuhiro MatsumotoMototsugu Oya

Abstract

To evaluate the recurrence and progression in patients with non-muscle-invasive bladder tumors who remained tumor-free for at least 5 years, which should assist in the development of schedules of their follow-up evaluations. Non-muscle-invasive bladder tumors that recur or progress at a late time point are not rare. Between 1985 and 2002, 814 cases diagnosed with non-muscle-invasive bladder cancer were treated with transurethral resection. Of these 814 cases, 262 patients with no tumor recurrence for more than 5 years were included in the study. The median follow-up interval was 10.0 years. During the follow-up period, 39 tumors (14.9%) showed tumor recurrence. The 5- and 10-year recurrence-free survival rates were 81.6% and 76.0%, respectively. There was no significant difference in tumor recurrence among the low-, intermediate-, and high-risk groups based on the current clinical guideline. Only the use of intravesical mitomycin C was determined to be a significant unfavorable risk factor for late recurrence. Five patients (1.9%) experienced stage progression, 3 of whom did not have metastases at the time of diagnosis of the progression but died because of bladder cancer disease. After a 5-year tumor-free period, even in the l...Continue Reading

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Citations

Nov 30, 2010·World Journal of Urology·Alon Z WeizerJeffrey S Montgomery
Oct 24, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Bernhard KissBeat Roth
Sep 22, 2018·Current Opinion in Urology·Iris S G BrummelhuisEdward M Messing
Oct 15, 2018·Journal of Cellular Physiology·Feng ZhaoRui-Peng Jia
Jan 9, 2020·The Cochrane Database of Systematic Reviews·Stefanie SchmidtJoerg J Meerpohl
Apr 25, 2019·Nature Reviews. Urology·Neus Martínez-BoschPilar Navarro
Dec 29, 2020·World Journal of Urology·J Alfred Witjes

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