Late recurrence in ovarian dysgerminoma with successful response to standard adjuvant chemotherapy: a case report and review of the literature

Gynecologic Oncology
A JeyakumarA Hindenburg

Abstract

Ovarian dysgerminomas are quite amenable to treatment and very good cure rates are achieved even with advanced disease. However, recent literature suggests that late recurrence may be associated with a poorer prognosis and bleomycin/etoposide/cisplatin (BEP) chemotherapy may play only a limited role in its management. We present a patient who had a late recurrence of ovarian dysgerminoma with successful treatment outcome. A 25-year-old woman was diagnosed with a stage IC ovarian dysgerminoma in 1983 and did not undergo adjuvant treatment. She had late recurrence 12 years later with good treatment response to BEP chemotherapy given in a semiadjuvant fashion. Our case demonstrates that BEP chemotherapy still plays an important role in treatment of late recurrence in ovarian dysgerminomas provided there is small volume disease at time of detection. Also important is long-term surveillance in an effort to detect recurrence while still small in volume and potentially curable.

References

Jul 1, 1995·Journal of Surgical Oncology·B PiuraM Glezerman
Dec 1, 1996·Gynecologic Oncology·A C CaseyR Farias-Eisner
Jan 16, 1999·Gynecologic Oncology·T Bekaii-SaabS D Williams

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Citations

Mar 13, 2012·Medical Oncology·Hamed A L HusainiIsmail A Al-Badawi
Jan 26, 2010·Gynecologic Oncology·Danielle VicusHelen Mackay
Feb 24, 2009·Journal of Pediatric and Adolescent Gynecology·Akihiro TakedaHiromi Nakamura
Feb 25, 2015·Journal of Forensic Sciences·Chittaranjan BeheraArvind Kumar

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