Late recurrence of renal cell carcinoma >5 years after surgery: clinicopathological characteristics and prognosis

BJU International
Yong Hyun ParkCheol Kwak

Abstract

What's known on the subject? and What does the study add? Late recurrence more than five years after the initial treatment is one of the biological behaviours specific for RCC. In our study, late recurrence was observed in 8.8% of the patients. Also, patients with late recurrence had more favorable clinicopathological features and better prognosis with long cancer-specific survival after recurrence. Age and preoperative hs-CRP levels may be independent predictive factors for late recurrence of RCC. • To evaluate the clinicopathological features and prognosis of late recurrence of renal cell carcinoma (RCC). • A total of 747 patients who had undergone curative surgery for RCC with follow-up of >5 years or recurrence within 5 years were included in the study. • The patients were stratified into four groups based on cancer-free intervals: no recurrence (no recurrence >5 years after surgery, n= 425), synchronous metastasis (n= 138), early recurrence (recurrence within 5 years, n= 143), and late recurrence (recurrence after 5 years, n= 41). • Multivariate analysis was performed to identify the clinicopathological factors affecting late recurrence and its clinical outcome. • The subgroups were significantly different in clinicopathol...Continue Reading

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Citations

Aug 26, 2014·Acta Oncologica·Siddhartha Yadav, Nabila Bennani-Baiti
Oct 1, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuhiro KobayashiYoshihiko Tomita
Jan 28, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sang Hyub LeeSeung Hyun Jeon
Jul 6, 2016·Journal of Experimental & Clinical Cancer Research : CR·Deng-Shuang WuLin-Hui Wang
Oct 6, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Clement Chung
Feb 3, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Chan Ho LeeUNKNOWN Korean Renal Cancer Study Group

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