Late reproductive analysis in rat male offspring exposed to nicotine during pregnancy and lactation

Andrology
M Miranda-SpoonerS M Miraglia

Abstract

We previously observed that nicotine, administered to rats (Wistar) during pregnancy and lactation periods, provokes, in the progeny, late morphofunctional alterations in Leydig cell, body weight increase in adulthood (90 days post partum, dpp) as well as seminiferous epithelium injury. Aiming to investigate whether the spermatogenic damage previously observed in adult progenies from pregnant and lactating nicotine-exposed rat dams are maintained or whether it is worsened in older rats, we analyzed the morphological testicular alterations after up to two complete periods of spermatogenesis (53 days each), spermatic parameters, and sperm DNA fragmentation. Pregnant and lactating rats were nicotine-exposed (2 mg/kg/day) through an osmotic minipump implanted on the first day of pregnancy and replaced after birth. Absolute Control (no minipump) and Sham Control (minipump without nicotine) groups were established. The offspring were killed at 90, 143, and 196 dpp. Significant alterations in morphometric and stereological testicular parameters, such as concentration of sperm number, daily sperm production, and plasma and intratesticular levels of cholesterol and testosterone were not observed in nicotine-exposed rats. Testicular hist...Continue Reading

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Citations

Apr 14, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Talita Biude MendesSandra Maria Miraglia
Jul 6, 2016·Archives of Toxicology·M GleiW Schlörmann
Jul 30, 2019·Frontiers in Endocrinology·Flávia Luciana BeltrameEstela Sasso-Cerri
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Santo K AntoGopabandhu Jena
Sep 5, 2020·Archives of Physiology and Biochemistry·Dalila RahaliNarges El Golli
Dec 30, 2017·International Journal of Experimental Pathology·Joana Noguères SimasSandra Maria Miraglia
Jan 1, 2021·Analytical Cellular Pathology (Amsterdam)·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda

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