PMID: 6988304Jan 1, 1980Paper

Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis

Gut
A P KirkS Sherlock

Abstract

A long-term follow-up of at least 10 years or until death of 44 patients taking part in a controlled prospective trial of prednisolone therapy in hepatitis B antigen negative chronic active hepatitis (lupoid hepatitis) has been performed at the Royal Free Hospital, London. Patients presenting between 1963 and 1967 were randomly allocated into control and treatment groups. Ten year life table survival curves showed a significantly improved survival in the treatment group where 63% of patients were alive at 10 years compared with only 27% in the control group (log rank test, P = 0.03). The median survival in the treatment group was 12.2 years compared with 3.3 years in the control group. The mean duration of treatment was 4.5 years. Age, presence of antinuclear factor, cirrhosis, or level of serum transaminases at presentation did not appear to affect survival. Male patients if untreated had a poorer prognosis than females (P = 0.02). The natural history of chronic active hepatitis appeared from clinical, biochemical, and histological findings to be from an active hepatitis or cirrhosis to inactive macronodular cirrhosis. Prednisolone therapy significantly improved survival by reducing mortality in the early active phase of the d...Continue Reading

References

Jan 1, 1975·Annual Review of Medicine·M A RothschildS S Schreiber
Nov 1, 1971·The American Journal of Digestive Diseases·M Eliastam, A W Holmes
Aug 1, 1973·Archives of Disease in Childhood·H G ClarkeD Putman
Apr 1, 1970·The American Journal of Medicine·S P Mistilis, C R Blackburn
Apr 1, 1971·The Quarterly Journal of Medicine·G C CookS Sherlock
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Mar 1, 1970·The Journal of Experimental Medicine·J Thompson, R van Furth
Jul 1, 1956·The American Journal of Medicine·A G BEARNR J SLATER

❮ Previous
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Citations

Aug 1, 1981·Digestive Diseases and Sciences·A W JakobovitsF J Dudley
Sep 1, 1995·Indian Journal of Pediatrics·E A Roberts
Jun 24, 2009·Clinical Reviews in Allergy & Immunology·Ziv Paz, Yehuda Shoenfeld
Sep 10, 2010·Hepatology International·Ye H OoDavid H Adams
Oct 1, 1980·The American Journal of Medicine·T B Reynolds
Feb 1, 1994·Steroids·F J FreyB M Frey
Jan 1, 1992·Pharmacology & Therapeutics·M Rojkind
Jan 1, 1989·Baillière's Clinical Gastroenterology·D R Triger
Oct 6, 2000·Journal of Hepatology·A Dhawan, G Mieli-Vergani
Nov 26, 2002·Journal of Hepatology·Jean François DufourJürg Reichen
May 4, 2011·Nature Reviews. Gastroenterology & Hepatology·Giorgina Mieli-Vergani, Diego Vergani
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Arndt VogelChristian P Strassburg
Aug 10, 1999·Journal of Gastroenterology and Hepatology·D Li, S L Friedman
Apr 4, 1996·The New England Journal of Medicine·J C Yarze
Apr 25, 2000·Journal of Clinical Gastroenterology·S P KaushikA C Clarke
Jan 12, 1999·Transplantation·E PradosE Fabrega
Sep 15, 2004·Journal of Clinical Gastroenterology·Bashar A AqelRolland C Dickson
Mar 1, 1993·Journal of Gastroenterology and Hepatology·G W McCaughan
Jan 4, 1998·Journal of Gastroenterology and Hepatology·M P Manns
Nov 1, 1994·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·S Reddi, A K Garg
Oct 1, 1982·Annals of the Rheumatic Diseases·H PerminJ O Nielsen
Jan 24, 1981·British Medical Journal·A K BurroughsS Sherlock
Aug 14, 1998·BMJ : British Medical Journal·D G Altman, J M Bland
Nov 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·K F KoK W Chan
Oct 1, 1989·Postgraduate Medical Journal·A R Tanner, A W Dellipiani
Nov 16, 2012·Therapeutic Advances in Gastroenterology·Richard ParkerDavid H Adams
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael A Heneghan, Ian G McFarlane
Jun 10, 2014·International Reviews of Immunology·Jessica Margaret SidoMitzi Nagarkatti
Nov 1, 1988·Scandinavian Journal of Gastroenterology·H Prytz, H Anderson
Jan 26, 2006·Expert Opinion on Pharmacotherapy·Michael A HeneghanIan G McFarlane
Nov 29, 2015·Journal of Autoimmunity·Qixia WangXiong Ma
Apr 29, 2011·Gastroenterology·Michael P Manns
Oct 20, 2010·Best Practice & Research. Clinical Gastroenterology·Christian P Strassburg
Jan 19, 2011·Autoimmunity Reviews·Katerina G OikonomouGeorge N Dalekos
Jul 6, 2010·Gastroenterology·Michael P MannsUNKNOWN European AIH-BUC-Study Group
Oct 9, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thawab Al-ChalabiMichael A Heneghan
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Johannes WiegandMichael P Manns
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke M HennesUNKNOWN International Autoimmune Hepatitis Group

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