PMID: 8950339Jan 1, 1997Paper

Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child

Medical and Pediatric Oncology
M S AshrafA D Pearson

Abstract

Although reversibility of acute ifosfamide-induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity.

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Citations

Mar 25, 2009·Expert Opinion on Drug Safety·Lauren HanlyGideon Koren
Feb 18, 2004·Pediatric Blood & Cancer·Thorsten LangerUNKNOWN German Late Effects Working Group in the German Society of Pediatric Oncology and Hematology
Sep 25, 2004·Pediatric Blood & Cancer·Edit BárdiCsongor Kiss
Nov 15, 2014·British Journal of Clinical Pharmacology·Lauren N FaughtKoren Gideon
Nov 6, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Daniel KittererJoerg Latus
Jul 18, 2003·Medical and Pediatric Oncology·R Skinner
Jun 7, 2006·Pediatric Blood & Cancer·Wolfgang StöhrRainer Rossi
Feb 24, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P E Kintzel
Jul 29, 2005·Canadian Journal of Physiology and Pharmacology·Katarina AleksaGideon Koren

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