Late seizures in patients initially seizure free after epilepsy surgery

Epilepsia
Theodore H SchwartzM R Sperling

Abstract

Surgery for medically intractable epilepsy is currently the most effective means of achieving seizure control. Although relatively few long-term outcome studies have been performed, evidence is mounting that the possibility of late seizure recurrence exists, even after an early seizure-free period. No published reports document the rate and predictors of late recurrence in a large series of patients undergoing surgery in the magnetic resonance imaging (MRI) era. We retrospectively queried the databases of two epilepsy surgery centers. Patients eligible for study had preoperative MRI scans, were seizure free for 1 year after surgery, and had a minimal follow-up period of 3 years. Patients with tumors or vascular lesions were excluded. We performed log-rank comparison of Kaplan-Meier product limit estimates for categoric variables and used a Cox proportional hazards model for continuous variables. Variables that were significant (p<0.05) on a univariate screen were entered into a multivariate forward step-wise Cox regression. The study included 285 patients, 254 with medial temporal lobe (MTLE) and 31 with neocortical epilepsy. The probability of having a single seizure after being seizure free for 1 year was 18.3% at 5 years and...Continue Reading

References

May 1, 1976·Acta Neurologica Scandinavica·I Jensen
Dec 1, 1992·Surgical Neurology·G ErbaG W Hornig
Nov 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·R D ElwesC E Polkey
Jan 1, 1993·Archives of Neurology·R KuznieckyA Bartolucci
Jun 1, 1996·Brain : a Journal of Neurology·V SalanovaL Quesney
Aug 14, 1996·JAMA : the Journal of the American Medical Association·M R SperlingC Plummer
Sep 1, 1996·Epilepsia·S S Spencer
Jul 13, 1999·Annals of Neurology·M R SperlingM J O'Connor
Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Jan 10, 2002·Journal of Neurosurgery·W BolingA Olivier
Oct 25, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·L JutilaA Ylinen
Sep 16, 2003·Epilepsy Research·Heinz-Gregor Wieser, Adrian Häne
Oct 2, 2003·Annals of Neurology·Christoph HelmstaedterChristian Erich Elger
Dec 25, 2003·Neurology·S S SpencerUNKNOWN Multicenter Study of Epilepsy Surgery
Jun 25, 2004·Brain : a Journal of Neurology·Anne M McIntoshSamuel F Berkovic
Mar 11, 2005·Brain : a Journal of Neurology·José F Téllez-ZentenoSamuel Wiebe

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Citations

Sep 16, 2010·Journal of Neurotrauma·Nick M E A HaywardAsla Pitkänen
Dec 25, 2008·Neurologia Medico-chirurgica·Kouzo MoritakeNobuo Hashimoto
Jul 3, 2010·Journal of Neurosurgery. Pediatrics·Ji Hoon PhiSeung-Ki Kim
Mar 14, 2007·Current Opinion in Neurology·Simon Shorvon, Anna Lisa Luciano
Aug 21, 2012·Anesthesiology Clinics·Jeffrey L KohTerrence McGraw
Dec 14, 2007·Epilepsy Research·Michael R SperlingAli A Asadi-Pooya
Aug 30, 2008·Epilepsia·Susanne Aull-WatschingerChristoph Baumgartner
Mar 16, 2013·Annals of Neurology·Thitiwan SimasathienLara Jehi
May 12, 2012·Acta Neurologica Scandinavica·J W PanS S Spencer
Oct 27, 2010·Annals of Neurology·Maria ThomEdward H Bertram
Nov 10, 2013·Epilepsia·Eduardo GoellnerDavid A Steven
Mar 5, 2010·Acta Neurologica Scandinavica·K Å AlfstadK O Nakken
Jul 12, 2012·Epilepsia·Stefanie P LazowBarbara C Jobst
Mar 19, 2014·Epilepsy Research·Sebastian HindeStephen Palmer
Jan 21, 2015·Epilepsia·Iván Sánchez FernándezTobias Loddenkemper
Jan 1, 2013·Epilepsy & Behavior Case Reports·Kyriakos GarganisBasilios Zountsas
May 24, 2014·Seizure : the Journal of the British Epilepsy Association·Jie MuHermann Stefan
Apr 3, 2010·Seizure : the Journal of the British Epilepsy Association·Orla DunleaNorman Delanty
Feb 26, 2013·Seizure : the Journal of the British Epilepsy Association·Anke M StaackBernhard J Steinhoff
Jan 24, 2007·Seizure : the Journal of the British Epilepsy Association·Muhammad Al-KaylaniBassel Abou-Khalil
Mar 1, 2011·Seizure : the Journal of the British Epilepsy Association·Alaa Eldin ElsharkawyAlois Ebner
Oct 28, 2016·Epilepsy & Behavior : E&B·Alexandra LiavaStefano Francione
May 17, 2018·PloS One·Midhun MohanUdo Wieshmann
Jul 2, 2015·The Cochrane Database of Systematic Reviews·Siobhan WestRichard Newton
Jun 27, 2019·The Cochrane Database of Systematic Reviews·Siobhan WestRichard Newton
Aug 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alican Tahta, Mehmet Turgut
Mar 30, 2021·Epilepsia·Stephan PetrikAndreas Schulze-Bonhage

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