Late sequelae of cochlear infection

The Laryngoscope
E M Keithley, J P Harris

Abstract

Inflammatory reactions within the inner ear are deleterious to cochlear function and can result in server hearing loss that does not recover. This study investigated a guinea pig model of long-term cytomegalovirus infection. At high doses active inflammation was still present after 35 days. At lower doses some ears showed partial resolution while others were still inflamed. Hearing was totally lost in all cases of persistent inflammation. There was some residual hearing in the cases that had resolved. Cochlear structures including the organ of Corti, stria vascularis, and spiral ganglion were partially degenerated. Fibrotic matrix within scala tympani was ossified in many cases. These changes are consistent with those described for human cochleas following putative viral infections.

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Citations

Jul 4, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Milind V KirtaneRajesh Patadiya
Jul 29, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mehdi BakhshaeeMohammadtaghi Shakeri
Jun 9, 1998·Annals of the New York Academy of Sciences·J P HarrisM C Chen
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Jan 4, 2013·PloS One·Patrick J AtkinsonRachael T Richardson
Mar 16, 2000·The Laryngoscope·C MaE M Keithley
Jan 25, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Xiaobo WangElizabeth M Keithley
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gregory C BarkdullJeffrey P Harris
Jul 15, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Shervin AminpourHilary A Brodie
Feb 14, 2012·International Journal of Pediatric Otorhinolaryngology·Cheol Hee ChoiByung Young Park
Dec 7, 2017·Frontiers in Cellular Neuroscience·Meiyan JiangPeter S Steyger
Sep 5, 2002·Acta Oto-laryngologica. Supplementum·Allen F RyanElizabeth M Keithley

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