Late spontaneous resolution of persistent molar pregnancy

BJOG : an International Journal of Obstetrics and Gynaecology
F TaylorR E Coleman

Abstract

To determine the outcome of women with persistently raised but falling human chorionic gonadotrophin (hCG) levels 6 months after surgical evacuation of a molar pregnancy. An 11-year retrospective review. The United Kingdom supra-regional trophoblastic disease treatment centres at Weston Park Hospital (Sheffield) and Charing Cross Hospital (London). Women with raised but falling serum human chorionic gonadotrophin (hCG) levels 6 months after evacuation of a molar pregnancy. Retrospective case note review of eligible women identified by the electronic databases held at each supra-regional centre. The proportion of women that attain normal hCG levels spontaneously without chemotherapy. In addition, rates of gestational trophoblastic neoplasia (GTN), drug resistance, disease relapse and overall survival are reported. Thirty-five women with molar pregnancy and raised but falling serum hCG levels continued surveillance 6 months after evacuation. Levels of hCG in 30 of the patients (86%) fell to normal levels spontaneously. One woman defaulted follow up prior to hCG normalisation (3%) and the remaining four women (11%) were treated with chemotherapy due to a plateau or rise in serum hCG levels indicating GTN. All treated women were su...Continue Reading

References

Dec 1, 1988·British Journal of Cancer·R A FisherK D Bagshawe
Jul 13, 2000·Lancet·M J SecklE S Newlands
Apr 4, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E I Kohorn
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I A McNeishE S Newlands
Jul 13, 2002·American Journal of Obstetrics and Gynecology·Glenn D Braunstein
May 16, 2003·American Journal of Obstetrics and Gynecology·Sarah A KhanlianLaurence A Cole
Oct 31, 2006·Molecular and Cellular Endocrinology·Hugh Mitchell, Michael J Seckl
May 8, 2007·Gynecologic Oncology·Carlo PalmieriMichael J Seckl
Nov 7, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Michael B Stone, Nancy E Conroy
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Aug 26, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Laurence A ColeTrefor N Higgins
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Mo'iad AlazzamTheresa A Lawrie
Oct 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hextan Y S NganJohn T Soper
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Mo'iad AlazzamTheresa A Lawrie
Jul 23, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F TaylorR E Coleman
Sep 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J SecklUNKNOWN ESMO Guidelines Working Group
Feb 18, 2014·Current Obstetrics and Gynecology Reports·Siew-Fei Ngu, Karen K L Chan
Dec 31, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip SavageAnthony Swerdlow

❮ Previous
Next ❯

Citations

Jan 28, 2009·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Sep 12, 2017·The Cochrane Database of Systematic Reviews·Qiuyi WangTheresa A Lawrie
Sep 23, 2019·Taiwanese Journal of Obstetrics & Gynecology·Asuka SatoMakio Shozu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.