Abstract
Traumatic brain injury (TBI) causes deficit in spatial learning and memory function. Physical activity ameliorates neurological dysfunction after TBI. We investigated the effect of late starting treadmill exercise on spatial learning ability in relation with cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway using TBI rats. For this study, radial 8-arm maze test, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) staining, caspase-3 immunohistochemistry, and western blot for Bax, Bcl-2, BDNF, tyrosine kinase B (TrkB), CREB, and phosphorylated CREP (p-CREB) were performed. TBI was induced by an electromagnetic-controlled cortical impact. The rats in the exercise groups were scheduled to run on a treadmill for 30 min once a day for 8 weeks starting 3 weeks after TBI. TBI impaired spatial learning ability and increased caspase-3 expression in the hippocampal dentate gyrus. TBI enhanced Bax expression and suppressed Bcl-2 expression in the hip-pocampus. TBI increased BDNF and TrkB expressions, resulted in the enhancement of p-CREB/CREB ratio in the hippocampus. However, treadmill exercise improved spatial learning ability, decreased caspase-3 expression...Continue Reading
Citations
Feb 1, 2019·Phytotherapy Research : PTR·Tingxu YanYing Jia
Dec 20, 2019·Animal Cells and Systems·Lakkyong HwangJae-Woo Yi
Dec 5, 2019·International Neurourology Journal·Hyungmo JeongJae Woo Yi
Jun 3, 2020·International Neurourology Journal·Myung-Soo JangJae-Woo Yi
Sep 17, 2019·Journal of Exercise Rehabilitation·Il-Gyu KoHong Kim
Jul 18, 2019·Nutrients·Hye-Sang ParkTae-Woon Kim
Mar 13, 2020·Journal of Exercise Rehabilitation·Su-Shin LeeBaek-Vin Lim
May 22, 2019·Journal of Exercise Rehabilitation·Min Chul LeeKijeong Kim
Apr 4, 2019·Frontiers in Cellular Neuroscience·Wei ZhangLibing Zhou
Sep 29, 2020·Journal of Biochemical and Molecular Toxicology·Lakkyong HwangBok Soon Chang
Jun 9, 2020·Journal of Exercise Rehabilitation·Tae-Won KimJung-Jun Park
Dec 7, 2020·Behavioural Brain Research·Laura Martínez-DrudisMargalida Coll-Andreu
Jan 21, 2021·Journal of Neurotrauma·Kate KarelinaZachary M Weil
Dec 4, 2020·International Neurourology Journal·Young Jun Ko, Il-Gyu Ko
Dec 4, 2020·International Neurourology Journal·Seunghwan LeeSunhyung Joo
Dec 4, 2020·International Neurourology Journal·Jeong Ho RhoJin Hee Han
Apr 3, 2020·International Immunopharmacology·Il-Gyu KoCheon Woong Choi
Mar 19, 2021·PloS One·Il-Gyu KoJin Hee Han
Apr 4, 2021·International Journal of Molecular Sciences·David GustafssonElham Rostami