Late steps of parvoviral infection induce changes in cell morphology

Virus Research
Kirsi PakkanenMatti Vuento

Abstract

Previously, virus-induced non-filopodial extensions have not been encountered in connection with viral infections. Here, we report emergence of long extensions protruding from Norden laboratory feline kidney (NLFK) and A72 (canine fibroma) cells infected with canine parvovirus for 72 h. These extensions significantly differ in length and number from those appearing in control cells. The most striking feature in the extensions is the length, reaching up to 130 microm, almost twice the average length of a healthy NLFK cell. In A72 cells, the extensions were even longer, up to 200 microm. The results presented here also suggest that the events leading to the growth of these extensions start earlier in infection and abnormal extension growth is detectable already at 24-h post-infection (p.i.). These extensions may have a vital role in the cell-to-cell transmission of the virus.

References

Dec 7, 1995·Nature·S CudmoreM Way
Apr 5, 2002·Journal of Virology·Sanna SuikkanenMatti Vuento
Sep 13, 2003·Journal of Virology·Sanna SuikkanenMaija Vihinen-Ranta
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Herman W FavoreelHans J Nauwynck
Dec 5, 2006·Cellular Microbiology·Larissa KolesnikovaStephan Becker
Feb 13, 2007·Nature Cell Biology·Nathan M ShererWalther Mothes

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