Latency and initiation of the human vestibuloocular reflex to pulsed galvanic stimulation

Journal of Neurophysiology
Swee T AwG Michael Halmagyi

Abstract

Cathodal galvanic currents activate primary vestibular afferents, whereas anodal currents inhibit them. Pulsed galvanic vestibular stimulation (GVS) was used to determine the latency and initiation of the human vestibuloocular reflex. Three-dimensional galvanic vestibuloocular reflex (g-VOR) was recorded with binocular dual-search coils in response to a bilateral bipolar 100-ms rectangular pulse of current at 0.9 (near-threshold), 2.5, 5.0, 7.5, and 10.0 mA in 11 normal subjects. The g-VOR consisted of three components: conjugate torsional eye rotation away from cathode toward anode; vertical divergence (skew deviation) with hypertropia of the eye on the cathodal and hypotropia of the eye on the anodal sides; and conjugate horizontal eye rotation away from cathode toward anode. The g-VOR was repeatable across all subjects, its magnitude a linear function of the current intensity, its latency about 9.0 ms with GVS of >or=2.5 mA, and was not suppressed by visual fixation. At 10-mA stimulation, the g-VOR [x, y, z] on the cathodal side was [0.77 +/- 0.10, -0.05 +/- 0.05, -0.18 +/- 0.06 degrees ] (mean +/- 95% confidence intervals) and on the anodal side was [0.79 +/- 0.10, 0.16 +/- 0.05, -0.19 +/- 0.06 degrees ], with a vertical di...Continue Reading

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Citations

Apr 9, 2009·Experimental Brain Research·Michael Barnett-Cowan, Laurence R Harris
Dec 15, 2012·Journal of the Association for Research in Otolaryngology : JARO·Swee T AwG Michael Halmagyi
Apr 25, 2012·The Journal of Physiology·Konrad P WeberKlara Landau
Sep 1, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Po-Wen ChengYi-Ho Young
Apr 18, 2016·Biological cybernetics·Christopher J NashRobert S Bigler
Mar 10, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sally M RosengrenJames G Colebatch
Nov 15, 2011·Neuron·David W Franklin, Daniel M Wolpert
Jan 27, 2015·Frontiers in Integrative Neuroscience·Patrick A ForbesJean-Sébastien Blouin
Oct 11, 2014·Experimental Brain Research·Hellen M Della-JustinaEdson Amaro
Aug 23, 2008·Progress in Brain Research·Konrad P WeberG Michael Halmagyi
Aug 2, 2008·Journal of Applied Physiology·Gregory Martin Lee SonJohn Timothy Inglis
Apr 18, 2019·Journal of Neurophysiology·Julia DlugaiczykHans Straka
Jul 11, 2014·Journal of Neurophysiology·Patrick A ForbesJean-Sébastien Blouin
Mar 1, 2012·Annals of the New York Academy of Sciences·Sergio CarmonaLilian Frankel
Jun 11, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Benjamin VailleauCatherine de Waele
Jul 28, 2016·BMC Bioinformatics·Arman SargolzaeiSaman Sargolzaei

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