Latent and subclinical tuberculosis in HIV infected patients: a cross-sectional study.

BMC Infectious Diseases
Meaghan M KallGraham H Bothamley

Abstract

HIV and tuberculosis (TB) are commonly associated. Identifying latent and asymptomatic tuberculosis infection in HIV-positive patients is important in preventing death and morbidity associated with active TB. Cross-sectional study of one time use of an interferon-gamma release assay (T-SPOT.TB - immunospot) to detect tuberculosis infection in patients in a UK inner city HIV clinic with a large sub-Saharan population. 542 patient samples from 520 patients who disclosed their symptoms of TB were tested. Median follow-up was 35 months (range 27-69). More than half (55%) originated from countries with medium or high tuberculosis burden and 57% were women. Antiretroviral therapy was used by 67%; median CD4 count at test was 458 cells/μl. A negative test was found in 452 samples and an indeterminate results in 40 (7.4%) but neither were associated with a low CD4 count. A positive test was found in 10% (50/502) individuals. All patients with positive tests were referred to the TB specialist, 47 (94%) had a chest radiograph and 46 (92%) attended the TB clinic. Two had culture-positive TB and a third individual with features of active TB was treated. 40 started and 38 completed preventive treatment. One patient who completed preventive ...Continue Reading

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Mar 28, 2013·The Lancet Infectious Diseases·Robert S WallisAlimuddin Zumla
Mar 22, 2016·Expert Review of Anti-infective Therapy·Ada W C LinPatrick C Y Woo
Apr 18, 2015·The European Respiratory Journal·Santino CapocciMarc Lipman
Apr 10, 2016·The Clinical Respiratory Journal·Parvaneh BaghaeiPayam Tabarsi
Feb 11, 2020·International Journal of STD & AIDS·Preeti SandhuFrank A Post
May 31, 2020·The Journal of Infection·Santino J CapocciMarc C I Lipman

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

STATA

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