Latent class analysis differentiation of adjustment disorder and demoralization, more severe depressive and anxiety disorders, and somatic symptoms in patients with cancer

Psycho-oncology
I BobevskiAnja Mehnert

Abstract

Demoralization as a form of existential distress involves poor coping, low morale, hopelessness, helplessness, and meaninglessness. In a secondary analysis of a cohort of German cancer patients, we aimed to explore latent class structure to assess the contribution that symptoms of demoralization make to anhedonic depression, anxiety, adjustment, and somatic disorders. Measures of demoralization, depression, anxiety, physical symptoms, and functional impairment had been completed cross-sectionally by 1527 patients with early or advanced cancer. Latent class analysis used maximum likelihood techniques to define the unobserved latent constructs that can be predicted as symptom clusters. Individual patients were assigned to the most probable class. Classes were compared on demographics, and logistic regression assessed the odds of individual items predicting each class. A 4-class model provided the best fit. Class 1 (n = 829, 54.3%) was defined by the absence of distress; Classes 2 to 4 all carried functional impairment. Class 2 (n = 333, 21.8%) was differentiated by somatic symptoms (sleep, tiredness, and appetite); Class 3 (n = 163, 10.7%) by anhedonia, anxiety, and severe demoralization; and Class 4 (n = 202, 13.2%) by adjustmen...Continue Reading

References

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Citations

Dec 27, 2019·Psycho-oncology·Peter HerschbachBirgitt Marten-Mittag
Jul 2, 2020·The Journal of Pharmacy and Pharmacology·Xiao-Dan ZhangJian-Chang Qian
Oct 12, 2018·Psycho-oncology·Sigrun Vehling, David W Kissane
Nov 19, 2020·Psycho-oncology·Luigi GrassiLuigi Zerbinati
Jun 17, 2021·Journal of Affective Disorders·Suzan SoydasPaul A Boelen
Jul 30, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Bianca SenfJens Fettel

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