Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi

Parasites & Vectors
Michelle ClementsG J van Dam

Abstract

Kato-Katz examination of stool smears is the field-standard method for detecting Schistosoma mansoni infection. However, Kato-Katz misses many active infections, especially of light intensity. Point-of-care circulating cathodic antigen (CCA) is an alternative field diagnostic that is more sensitive than Kato-Katz when intensity is low, but interpretation of CCA-trace results is unclear. To evaluate trace results, we tested urine and stool specimens from 398 pupils from eight schools in Burundi using four approaches: two in Burundi and two in a laboratory in Leiden, the Netherlands. In Burundi, we used Kato-Katz and point-of-care CCA (CCAB). In Leiden, we repeated the CCA (CCAL) and also used Up-Converting Phosphor Circulating Anodic Antigen (CAA). We applied Bayesian latent class analyses (LCA), first considering CCA traces as negative and then as positive. We used the LCA output to estimate validity of the prevalence estimates of each test in comparison to the population-level infection prevalence and estimated the proportion of trace results that were likely true positives. Kato-Katz yielded the lowest prevalence (6.8%), and CCAB with trace considered positive yielded the highest (53.5%). There were many more trace results re...Continue Reading

References

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Citations

Nov 9, 2018·PLoS Neglected Tropical Diseases·José M Peralta, Marta G Cavalcanti
May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Eugene RuberanzizaMichelle N Clements
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Charles H KingDaniel G Colley
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Daniel G ColleySue Binder
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·N Robert Bergquist
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Sue BinderDaniel G Colley
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Paul L A M CorstjensGovert J van Dam
Oct 3, 2018·Tropical Medicine and Infectious Disease·W Evan Secor, Daniel G Colley
Nov 30, 2018·Frontiers in Immunology·Claudia J de DoodPaul L A M Corstjens
Apr 4, 2019·Memórias do Instituto Oswaldo Cruz·Vanessa Silva-MoraesPaulo Marcos Zech Coelho
Feb 5, 2021·PLoS Neglected Tropical Diseases·Artemis KoukounariIrini Moustaki
Mar 23, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Enas A El Saftawy

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Software Mentioned

R2OpenBugs
LCA
BetaBuster
R
OpenBugs

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