Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway

Frontiers in Immunology
Chongfeng XuZiyuan Duan

Abstract

RIG-I signaling is critical to host innate immune response against RNA virus infection, and also can be activated against many kinds of cancer. Oncogene LMP1 of Epstein-Barr virus (EBV) contributes to various tumors progress. In this study, we have provided strong evidence that LMP1 inhibits Sendai virus mediated type I interferon production and downregulates RIG-I signaling pathway by promotion RIG-I degradation dependent on proteasome. Nineteen kinds of E3 ligase are identified by IP-MS as LMP1-interactors, they are candidate E3s, which are possibly recruited by LMP1 to mediate RIG-I degradation. CHIP is among these E3s, which has been reported to lead RIG-I degradation. Notably, we find C666-1, an EBV-positive nasopharyngeal carcinoma cell line, expresses low level of RIG-I, even treated with IFN-α, RIG-I expression could not be induced. This evidence indicates that EBV employs a unique strategy to evade RIG-I mediated immune responses.

References

Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Nov 4, 2008·Nature Medicine·Hendrik PoeckGunther Hartmann
Nov 16, 2010·Neoplasia : an International Journal for Oncology Research·Tomonori KatoYoshikazu Yonemitsu
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Taeko Matsushima-MiyagiYasufumi Kaneda
Nov 3, 2012·RNA·Daniel KolakofskyStephen Cusack
Feb 19, 2013·Expert Opinion on Therapeutic Targets·Tsukasa SeyaMisako Matsumoto
Jun 20, 2014·Journal of Clinical and Experimental Hematopathology : JCEH·Tsugumi SatohSoroku Yagihashi
Dec 24, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kai ZhaoXuetao Cao
Apr 2, 2016·Oncotarget·Diana Rose E RanoaNikolai N Khodarev
Jun 9, 2017·Protein & Cell·Xiao-Xiao XuJian-Zhong Shao
Sep 7, 2017·Journal of Innate Immunity·Yuanjun LuJian Ma
Sep 18, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Yuanbing WuZhiping Liu
Oct 11, 2017·Journal of Cellular and Molecular Medicine·Jinglin ZhangWei Kang
Oct 24, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pingsen ZhaoXianzhu Xia
Nov 1, 2017·Recent Patents on Anti-cancer Drug Discovery·Sandra IuresciaMonica Rinaldi

❮ Previous
Next ❯

Citations

Dec 13, 2019·Experimental & Molecular Medicine·Hyun-Cheol LeeJong-Soo Lee
Jul 28, 2020·BioMed Research International·Qingxun ZhangZiyuan Duan
Jun 27, 2019·Microorganisms·Sonia JangraDong-Yan Jin
Jun 23, 2021·Journal of Experimental & Clinical Cancer Research : CR·Ramon YarzaLara Carmen Iglesias-Docampo

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
protein assay
co-immunoprecipitation
ubiquitination
Co-IP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Cui-mei LiGuang-liang Han
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Xiang YiWeimin Zhao
© 2022 Meta ULC. All rights reserved