Latent Phase Identification of High-Frequency Micro-Scale Gamma Spike Transients in the Hypoxic Ischemic EEG of Preterm Fetal Sheep Using Spectral Analysis and Fuzzy Classifiers

Sensors
Hamid AbbasiCharles P Unsworth

Abstract

Premature babies are at high risk of serious neurodevelopmental disabilities, which in many cases are related to perinatal hypoxic-ischemic encephalopathy (HIE). Studies of neuroprotection in animal models consistently suggest that treatment must be started as early as possible in the first 6 h after hypoxia-ischemia (HI), the so-called latent phase before secondary deterioration, to improve outcomes. We have shown in preterm sheep that EEG biomarkers of injury, in the form of high-frequency micro-scale spike transients, develop and evolve in this critical latent phase after severe asphyxia. Real-time automatic identification of such events is important for the early and accurate detection of HI injury, so that the right treatment can be implemented at the right time. We have previously reported successful strategies for accurate identification of EEG patterns after HI. In this study, we report an alternative high-performance approach based on the fusion of spectral Fourier analysis and Type-I fuzzy classifiers (FFT-Type-I-FLC). We assessed its performance in over 2520 min of latent phase EEG recordings from seven asphyxiated in utero preterm fetal sheep exposed to a range of different occlusion periods. The FFT-Type-I-FLC clas...Continue Reading

References

Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sherly GeorgeLaura Bennet
Apr 5, 2008·Current Opinion in Obstetrics & Gynecology·Alistair J Gunn, Laura Bennet
Oct 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·W DeburchgraeveS Van Huffel
Oct 20, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jonathan J Halford
Feb 18, 2010·Current Opinion in Neurology·Anatol BraginRichard J Staba
Jul 22, 2010·Seminars in Fetal & Neonatal Medicine·L BennetA J Gunn
Jun 8, 2011·The Journal of Physiology·Joanne O DavidsonLaura Bennet
Apr 7, 2012·Progress in Neurobiology·J JacobsJ Gotman
May 19, 2012·Nature Reviews. Neuroscience·György BuzsákiChristof Koch
Dec 25, 2012·Journal of Neuroscience Methods·Gwénaël BirotFabrice Wendling
Feb 15, 2014·Clinics in Perinatology·Paul P DruryAlistair J Gunn
May 2, 2015·Resuscitation·Alistair J Gunn, Marianne Thoresen
Dec 29, 2015·Lancet Neurology·Alistair J Gunn, Laura Bennet
Feb 10, 2016·Journal of Neural Engineering·Quang M TiengDavid C Reutens
Feb 11, 2016·World Journal of Clinical Pediatrics·Caroline E AhearneDeirdre M Murray
Sep 15, 2017·IEEE Journal of Biomedical and Health Informatics·Amir Hossein AnsariSabine Van Huffel
May 12, 2018·International Journal of Neural Systems·Amir H AnsariSabine Van Huffel
Nov 14, 2019·Neural Regeneration Research·Hamid Abbasi, Charles P Unsworth

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