Latent porcine circovirus type 2-infected domestic pigs: A potential infection model for the effective development of vaccines against latent or chronic virus induced diseases

Vaccine
Titus SydlerEnrico Brugnera

Abstract

Until recently, knowledge of the pathogenicity of Circoviridae and Anelloviridae family members was limited. Our previous discoveries provided clues toward resolving this issue based on studies of the latent nature of porcine circovirus type 2 (PCV2) genotype group members. We developed a conventional pig infection model that indicated that weaners already harbored latent PCV2 infection in the thymus, which enabled the viruses to specifically modulate the maturation of T-helper cells. This finding raised the possibility that the thymi of normal fetuses were already infected with PCV2. The present findings further substantiate our hypothesis that PCV2 masquerades as the host by infecting fetuses before they acquire immune-competence. We provide the first demonstration that all domestic pig fetuses preferentially harbor latent PCV2-infected cells in their thymi. These PCV2-infected cells are different from thymocytes and are located in the medulla of the fetal thymus. These latent PCV2-infected cells in fetuses are found at the same location and share characteristics with the infected cells observed in adolescent pigs. Moreover, fetuses also harbor these infected cells in other lymph system organs. We provide the first demonstrat...Continue Reading

References

Sep 13, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·K H WestJ A Ellis
Oct 18, 2003·Avian Diseases·Myrna M MillerKarel A Schat
Mar 2, 2005·Journal of Comparative Pathology·J-S ParkC Chae
Apr 6, 2006·Animal Health Research Reviews·Joaquim SegalésMariano Domingo
Nov 24, 2006·Avian Pathology : Journal of the W.V.P.A·Amir KaffashiGlenn F Browning
Dec 17, 2008·Veterinary Microbiology·Danja D WiederkehrXaver Sidler
May 20, 2009·Virology Journal·Florence FaurezAndré Jestin
Aug 4, 2009·PLoS Pathogens·Michael B A Oldstone
May 11, 2010·Veterinary Immunology and Immunopathology·T KekarainenG M Allan
Dec 20, 2011·Virus Research·Nicolas RoseAndré Jestin
Feb 24, 2012·Gut Microbes·Hsin-Jung Wu, Eric Wu
May 23, 2012·Emerging Infectious Diseases·Fabrizio MaggiMauro Pistello
Oct 3, 2012·Schweizer Archiv für Tierheilkunde·M BaumgartnerX Sidler
May 11, 2013·Expert Review of Vaccines·Daniel O VillarrealDavid B Weiner
Jul 23, 2013·Veterinary Microbiology·Cheryl M T DvorakMichael P Murtaugh
Aug 24, 2013·Emerging Infectious Diseases·Saskia L SmitsAlbert D M E Osterhaus
Oct 1, 2013·Virology·Tung Gia PhanEric Delwart
Oct 30, 2013·Journal of Oral Microbiology·Bjørn Grinde

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