Latent toxoplasma infection in real-world schizophrenia: Results from the national FACE-SZ cohort

Schizophrenia Research
G FondFACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group.

Abstract

Latent Toxoplasma infection has been associated with widespread brain immune activation, increased blood brain barrier permeability, neural disruption, increased dopamine release in dopaminergic neurons, with NMDA activation and with schizophrenia (SZ) onset risk. Toxoplasma has been suggested to be a source of chronic low-grade inflammation and this inflammation has been associated with cognitive impairment in SZ. The objective of the present study were (i) to determine if latent Toxoplasma infection was associated with specific clinical features in stabilized SZ subjects, with cognitive impairment and with increased low-grade peripheral inflammation and (ii) to determine if Treatments with Anti-Toxoplasmic Activity (TATA) were associated with improved outcomes in subjects with latent Toxoplasma infection. A comprehensive 2 daylong clinical and neuropsychological battery was administered in 250 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Solid phase-enzyme microplate immunoassay methods were used to measure IgG class of antibodies to T. gondii in blood sample. Latent Toxoplasma infection was defined by T. gondii IgG ratio ≥0.8, equivalent to ≥10 international units. Ch...Continue Reading

Citations

Sep 24, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Santiago M FernandesÂngela Miranda-Scippa
Apr 8, 2020·Frontiers in Psychiatry·Guillaume FondLaurent Boyer
Mar 29, 2020·European Archives of Psychiatry and Clinical Neuroscience·Maija LindgrenJaana Suvisaari
May 26, 2020·BMC Public Health·Eissa SoleymaniYounes Mohammadi
Apr 22, 2020·Microbial Pathogenesis·Mohammad-Mahdi GhanbariMohammad Sayyah
Jun 29, 2021·Frontiers in Psychiatry·Teodor T PostolacheLisa A Brenner

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