Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru

PloS One
Moises A HuamanCarl J Fichtenbaum

Abstract

We previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic setting, we assessed interferon-gamma levels in persons with and without LTBI in Peru. We analyzed data from patients with and without a recent type 1 (spontaneous) acute myocardial infarction (AMI) who were enrolled from two public hospital networks in Lima, Peru, and underwent LTBI testing using the QuantiFERON® TB Gold In-tube (QFT) assay. Participants with a positive QFT test were defined as having LTBI, whereas participants with a negative QFT test were defined as non-LTBI. Unstimulated interferon-gamma was quantified via enzyme-linked immunosorbent assay in the QFT nil-tube, which does not contain antigens. We compared unstimulated interferon-gamma levels between LTBI and non-LTBI groups using the Wilcoxon rank sum test. We used proportional odds modeling for multivariable analysis. Data from 214 participants were included in this analysis. Of those, 120 (56%) had LTBI. There were no significant differences in age, sex and comorbidities between LTBI and non-LTBI participants, excep...Continue Reading

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Nov 18, 2016·Pathogens & Immunity·Moises A HuamanCarl J Fichtenbaum
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Oct 27, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Moises A HuamanBeth A Garvy

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Citations

Apr 14, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephanie LaVergneAjay R Bharti
Jan 5, 2021·Frontiers in Immunology·Moises A HuamanDavid Y Hui
Dec 1, 2020·AIDS·Moises A HuamanChris T Longenecker
Feb 16, 2021·Frontiers in Immunology·Shilpa NaikRupak Shivakoti

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Stata

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