Latent varicella-zoster virus is located predominantly in neurons in human trigeminal ganglia

Proceedings of the National Academy of Sciences of the United States of America
P G KennedyJ W Gow

Abstract

Varicella-zoster virus (VZV) is a human herpesvirus that causes varicella (chicken pox) as a primary infection and, after a variable period of latency in trigeminal and dorsal root ganglia, reactivates to cause herpes zoster (shingles). Both of these conditions may be followed by a variety of neurological complications, especially in immunocompromised individuals such as those with human immunodeficiency virus (HIV) infection. There have been a number of conflicting reports regarding the cellular location of latent VZV within human ganglia. To address this controversy we examined fixed wax-embedded trigeminal ganglia from 30 individuals obtained at autopsy, including 11 with HIV infection, 2 neonates, and 17 immunocompetent individuals, for the presence of latent VZV. Polymerase chain reaction (PCR), in situ hybridization, and PCR in situ amplification techniques with oligonucleotide probes and primer sequences to VZV genes 18, 21, 29, and 63 were used. VZV DNA in ganglia was detected in 15 individuals by using PCR alone, and in 12 individuals (6 normal non-HIV and 6 positive HIV individuals, but not neonatal ganglia) by using PCR in situ amplification. When in situ hybridization alone was used, 5 HIV-positive individuals and o...Continue Reading

References

Aug 1, 1992·The Journal of Infectious Diseases·T H Weller
Aug 1, 1992·The Journal of Infectious Diseases·J L Meier, S E Straus
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K D CroenS E Straus
Oct 8, 1983·Lancet·R W HymanR B Tenser
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·O LunguS J Silverstein
Jun 1, 1995·Annals of Neurology·C Amlie-LefondD H Gilden
Jan 1, 1993·Molecular Neurobiology·I Steiner, P G Kennedy
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·R MahalingamD H Gilden

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Citations

Sep 5, 2002·Reviews in Medical Virology·Peter G E Kennedy
Jun 19, 2007·Pediatric Radiology·Henry J Baskin, Gary Hedlund
Mar 20, 2002·Current Neurology and Neuroscience Reports·R B Tenser
Oct 22, 2003·Journal of the Neurological Sciences·Peter G E KennedyMargaret M Esiri
Mar 4, 2000·The New England Journal of Medicine·D H GildenR J Cohrs
Jul 5, 2002·The New England Journal of Medicine·Atsuko HataAnn M Arvin
May 3, 2008·The Journal of Infectious Diseases·Anne A GershonMichael D Gershon
Oct 30, 2003·Viral Immunology·Donald H GildenRavi Mahalingam
Sep 15, 2001·Brain Pathology·R J Cohrs, D H Gilden
Jun 29, 2012·Journal of Virology·Werner J D OuwendijkGeorges M G M Verjans
Jun 20, 2002·Journal of Virology·Randall J CohrsDonald H Gilden
May 28, 2003·Journal of Virology·Randall J CohrsPeter G E Kennedy
May 28, 2003·Journal of Virology·Myron J LevinLewis I Pizer
Jan 1, 2009·BMJ Case Reports·Asaf PeretzIsrael Steiner
Jul 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Asaf PeretzIsrael Steiner
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·P G E Kennedy
Nov 20, 2012·Case Reports in Ophthalmology·Akio MiyakoshiAtsushi Hayashi
May 16, 2013·PLoS Pathogens·Werner J D OuwendijkGeorges M G M Verjans
Dec 1, 2009·Future Neurology·Don GildenRandall J Cohrs
Jul 8, 2010·Aging Health·Joel V Chua, Wilbur H Chen
Jun 23, 2011·Future Virology·Emily EshlemanRandall J Cohrs
Nov 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael P H StumpfVincent A A Jansen
Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Armin BaikerAnn M Arvin
Aug 2, 2012·Journal of Neurovirology·Yevgeniy AzarkhRandall J Cohrs
Aug 7, 2013·Journal of Neurovirology·Maria A Nagel
Feb 5, 2016·Journal of Neurovirology·Hussain BadaniMaria A Nagel
Aug 5, 2000·Mayo Clinic Proceedings·T J Liesegang
Dec 18, 2013·Journal of Medical Virology·Marius BirleaDon Gilden
Oct 20, 2007·Lancet Neurology·Israel SteinerAndrew R Pachner
Oct 12, 2015·Journal of the Neurological Sciences·Kristin M Galetta, Don Gilden
Feb 24, 2011·Neuropathology and Applied Neurobiology·D GildenR J Cohrs
Sep 27, 2014·The Journal of Pathology·Werner Jd Ouwendijk, Georges Mgm Verjans

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