Abstract
Advanced paternal age is consistently associated with an increased risk for schizophrenia, accounting for up to a quarter of cases in some populations. If paternal age-related schizophrenia (PARS) involves a distinct etiopathology, then PARS cases may show specific characteristics, vis-à-vis other schizophrenia cases. This study examined if PARS exhibits the symptom profile and sex differences that are consistently observed for schizophrenia in general, wherein males have an earlier onset age and more severe negative symptoms than females. Symptoms were assessed at baseline (admission) and during medication-free and treatment phases for 153 inpatients on a schizophrenia research unit, 38 of whom fulfilled operationally defined criteria for PARS (sporadic cases with paternal age > or = 35). Males and females with PARS had the same age at onset and a similar preponderance of negative symptoms, whereas the other (non-PARS) cases showed the typical earlier onset age and more severe negative symptoms in males. When medications were withdrawn, PARS cases showed significantly worse symptoms than non-PARS cases (higher total PANSS scores and positive, activation, and autistic preoccupation scores). However these symptoms globally impro...Continue Reading
References
Apr 25, 2001·Archives of General Psychiatry·D MalaspinaE S Susser
Mar 29, 2002·American Journal of Medical Genetics·Dolores MalaspinaJack Gorman
Aug 31, 2002·The American Journal of Psychiatry·Alan S BrownEzra S Susser
Aug 31, 2002·The American Journal of Psychiatry·Christina Dalman, Peter Allebeck
Nov 5, 2003·The British Journal of Psychiatry : the Journal of Mental Science·Stanley ZammitGlyn Lewis
Feb 27, 2004·Schizophrenia Research·Ossama El-SaadiJohn McGrath
Oct 27, 2004·BMJ : British Medical Journal·Attila SiposDavid Gunnell
Citations
Oct 23, 2013·Schizophrenia Research·Mark OplerDavid Hough
Dec 19, 2012·Psychological Medicine·M van der WerfJ Allardyce
Aug 23, 2012·Schizophrenia Research·Brandon AbbsLynn E Delisi
Jan 9, 2016·Neuroscience and Biobehavioral Reviews·Adrianna Mendrek, Adham Mancini-Marïe
Jul 16, 2011·Schizophrenia Research·Arielle D StanfordCheryl M Corcoran
Mar 1, 2011·Schizophrenia Research·Hyejoo LeeDaniel Antonius
Aug 19, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mary PerrinDolores Malaspina
Aug 1, 2014·Molecular Genetics & Genomic Medicine·Dolores MalaspinaMary C Perrin
Jul 18, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Douglas S LehrerCarlos N Pato
Apr 18, 2015·Fertility and Sterility·Ranjith RamasamyDolores J Lamb
Oct 18, 2011·Schizophrenia Research·Emma M FransChristina M Hultman
Feb 14, 2014·PloS One·Debby TsuangAllen Radant
Jul 15, 2016·Psychiatry Research·Rudolf LiebenbergJ Louw Roos
Mar 1, 2019·PloS One·Laura A SteenhuisAgna A Bartels-Velthuis
Oct 12, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Christy L M HuiEric Y H Chen
Nov 18, 2020·Human Reproduction·Vincent CoutureGuido Pennings
Mar 7, 2021·Pediatric Research·Ine VervoortAdelheid Soubry
Aug 25, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Ashok Kumar JyothiHannah Sugirthabai Rajila