Jun 1, 2000

Lateral gene transfer and the nature of bacterial innovation

Nature
H OchmanEduardo A Groisman

Abstract

Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms. Horizontal gene transfer produces extremely dynamic genomes in which substantial amounts of DNA are introduced into and deleted from the chromosome. These lateral transfers have effectively changed the ecological and pathogenic character of bacterial species.

  • References49
  • Citations1342

Mentioned in this Paper

Antibiotic Resistance, Microbial
Pathogenicity
Genome
Pathogenic Organism
Bacteriophages
Recombination, Genetic
Gene Transfer, Horizontal
Transformation, Bacterial
Genes, Bacterial
Chromosomes

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