Lateral hypothalamic circuits for feeding and reward

Nature Neuroscience
Garret D Stuber, Roy A Wise

Abstract

In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding even in well-fed animals. In the absence of food, animals will work tirelessly, often lever-pressing thousands of times per hour, for electrical stimulation at the same site that provokes feeding, drinking and other species-typical motivated behaviors. Here we review the classic findings from electrical stimulation studies and integrate them with more recent work that has used contemporary circuit-based approaches to study the LHA. We identify specific anatomically and molecularly defined LHA elements that integrate diverse information arising from cortical, extended amygdala and basal forebrain networks to ultimately generate a highly specified and invigorated behavioral state conveyed via LHA projections to downstream reward and feeding-specific circuits.

References

Aug 1, 1978·Journal of Comparative and Physiological Psychology·G FouriezosR A Wise
Aug 1, 1978·The Journal of Comparative Neurology·R Y MooreB E Jones
May 1, 1979·Physiology & Behavior·J S Yeomans
Aug 25, 1978·Brain Research·R A Wise
Jul 1, 1979·Pharmacology, Biochemistry, and Behavior·K B Franklin, S N McCoy
Dec 1, 1978·Pharmacology, Biochemistry, and Behavior·K B Franklin
May 8, 1992·The Journal of Comparative Neurology·J C BittencourtP E Sawchenko
Nov 15, 1988·The Journal of Comparative Neurology·E A Grove
Dec 1, 1986·Brain Research Bulletin·M FukudaK Nakamura
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·G Kapatos, R M Gold
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
May 1, 1973·Behavioral Biology·J Mendelson, W J Freed
Sep 1, 1973·Behavioral Biology·R A Wise, J Albin
Oct 1, 1969·Brain Research·O E Millhouse
Jul 30, 1969·Annals of the New York Academy of Sciences·J P Flynn
Jun 3, 1966·Science·M F MacDonnell, J P Flynn
Mar 1, 1967·Psychological Review·S E Glickman, B B Schiff
Sep 9, 1966·Science·A R Caggiula, B G Hoebel
Jun 1, 1966·Journal of Comparative and Physiological Psychology·R R Hutchinson, J W Renfrew
Oct 1, 1966·Animal Behaviour·M MacDonnell, J P Flynn
Feb 1, 1967·Experimental Neurology·G J Mogenson, J A Stevenson
Mar 20, 1982·The Journal of Comparative Neurology·R NieuwenhuysJ G Veening
May 1, 1981·Psychological Review·C R GallistelJ S Yeomans

❮ Previous
Next ❯

Citations

May 6, 2016·Annual Review of Neuroscience·Hailan Hu
Jan 31, 2017·International Journal of Molecular Sciences·Ken HowickHarriët Schellekens
Jan 31, 2017·Nature Neuroscience·Jenna A McHenryGarret D Stuber
Dec 4, 2016·Annual Review of Physiology·Scott M Sternson, Anne-Kathrin Eiselt
Apr 21, 2017·Nature Communications·Akira MutoKoichi Kawakami
Aug 30, 2016·Neuroscience and Biobehavioral Reviews·R J Rodgers
Oct 28, 2016·Behavioural Brain Research·Amita R SomalwarDadasaheb M Kokare
Jul 16, 2016·Behavioural Brain Research·Nanette Y SchneiderGérard Coureaud
Mar 11, 2017·Trends in Endocrinology and Metabolism : TEM·Patrick Sweeney, Yunlei Yang
Nov 26, 2016·Frontiers in Neuroendocrinology·Carolina Gutierrez HerreraAntoine Adamantidis
Jun 19, 2017·Pharmacology, Biochemistry, and Behavior·Avi ShahJiang-Hong Ye
Jun 9, 2017·Disease Models & Mechanisms·Katharina Timper, Jens C Brüning
Jan 6, 2017·Nature Reviews. Neuroscience·Marisela Morales, Elyssa B Margolis
Jul 1, 2017·Nature Reviews. Endocrinology·Emanuel GasserRonald M Evans
Jul 22, 2016·Brain Sciences·Ruth FrancoClement Hamani
Oct 25, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I H HardingA Verdejo-Garcia
Feb 24, 2018·The Journal of Comparative Neurology·Cindy F Yang, Jack L Feldman
Jan 13, 2018·Frontiers in Systems Neuroscience·Toshiharu IchinoseNobuhiro Yamagata
Apr 29, 2018·Journal of Neurochemistry·Rachel E ClarkeZane B Andrews
Aug 1, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Sofia Uribe-CerdaClaudio Perez-Leighton
Oct 9, 2018·Addiction Biology·Sheng ZhangChiang-Shan R Li
Sep 15, 2018·Endocrinology·Emily Qualls-Creekmore, Heike Münzberg
Sep 2, 2017·Neurosurgical Focus·Daniel A N BarbosaAntonio A F De Salles
Mar 21, 2019·PLoS Biology·Fumito NaganumaRamalingam Vetrivelan
Feb 14, 2019·Molecular Psychiatry·Iakovos LazaridisKonstantinos Meletis
Dec 17, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Olalekan M OgundeleJoseph Francis
Jul 11, 2019·PloS One·Felipe L SchiffinoYeka Aponte
Oct 9, 2019·Journal of Huntington's Disease·Rachel Y CheongÅsa Petersén
Dec 25, 2019·The Journal of Comparative Neurology·Nanette Y SchneiderJean Gascuel
Mar 21, 2020·Endocrinology·Juan H Vasquez, Jeremy C Borniger
Oct 9, 2019·Nature Communications·Ou FuKen-Ichiro Nakajima
Aug 28, 2020·Endocrinology·Kimberly J Jennings, Luis de Lecea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.