Lateral interaction of cholesterol with a semifluorinated amphiphile at the air-water interface

Colloids and Surfaces. B, Biointerfaces
Hiromichi NakaharaOsamu Shibata

Abstract

Lipid rafts consisting mainly of sphingomyelin and cholesterol (Ch) on biomembrane surfaces are deeply related to cellular processes such as protein trafficking and signal transduction. During the processes, the raft microdomains affect the fluidty of biological membranes, which is controlled to large extents by Ch. In this paper, we have investigated the interaction between Ch and a semiflurinated alcohol (F6H9OH) from the aspect of a fluidty control using surface chemistry. The two-component Langmuir monolayer at the air-water interface was characterized by the surface pressure (π)-molecular area (A) and surface potential (ΔV)-A isotherms. The compressibility modulus and excess Gibbs free energy of mixing were calculated from the π-A isotherms. And also the two-dimensional phase diagram was constructed on the basis of phase transition pressures and monolayer collapse pressures. Furthermore, the phase behavior of binary monolayers was visualized with fluorescence microscopy (in situ) and atomic force microscopy (ex situ). The result here indicates a possibility of fluidity control of Ch-related membranes by arranging the fluorination degree of the constituent lipids.

References

Nov 27, 1990·Biochemistry·M B Sankaram, T E Thompson
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Jul 21, 1981·Biochemistry·D J Recktenwald, H M McConnell
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R Peters, K Beck
Nov 15, 1996·The Journal of Biological Chemistry·E J SmartR G Anderson
Jun 5, 1997·Nature·K Simons, E Ikonen
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A Brown
Feb 16, 2002·European Journal of Biochemistry·Laura D Zajchowski, Stephen M Robbins
Oct 7, 2004·Journal of Colloid and Interface Science·M BroniatowskiP Dynarowicz-Łatka
Mar 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·I Rey Gómez-SerranillosE Iribarnegaray
Mar 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Marcin Broniatowski, Patrycja Dynarowicz-Łatka
Jul 13, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Marcin Broniatowski, Patrycja Dynarowicz-Łatka
Jun 10, 2009·Journal of Colloid and Interface Science·Hiromichi NakaharaOsamu Shibata
Nov 6, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Hiromichi NakaharaOsamu Shibata
Oct 31, 2012·Colloids and Surfaces. B, Biointerfaces·Hiromichi NakaharaOsamu Shibata

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Citations

Apr 14, 2020·Journal of Oleo Science·Masataka YoshidaKen-Ichi Iimura
Aug 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Kento KannakaTakahiro Mukai

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