Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry

International Journal of Molecular Sciences
Rodion J MolotkovskyS A Akimov

Abstract

Sphingomyelin- and cholesterol- enriched membrane domains, commonly referred to as "rafts" play a crucial role in a large number of intra- and intercellular processes. Recent experiments suggest that not only the volumetric inhomogeneity of lipid distribution in rafts, but also the arrangement of the 1D boundary between the raft and the surrounding membrane is important for the membrane-associated processes. The reason is that the boundary preferentially recruits different peptides, such as HIV (human immunodeficiency virus) fusion peptide. In the present work, we report a theoretical investigation of mechanisms of influence of the raft boundary arrangement upon virus-induced membrane fusion. We theoretically predict that the raft boundary can act as an attractor for viral fusion peptides, which preferentially distribute into the vicinity of the boundary, playing the role of 'line active components' of the membrane ('linactants'). We have calculated the height of the fusion energy barrier and demonstrated that, in the case of fusion between HIV membrane and the target cell, presence of the raft boundary in the vicinity of the fusion site facilitates fusion. The results we obtained can be further generalized to be applicable to ...Continue Reading

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Citations

Nov 16, 2019·Biomolecules·Rodion J MolotkovskySergey A Akimov
Feb 23, 2020·PLoS Pathogens·Charles A CoomerSergi Padilla-Parra
Jun 4, 2020·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Nov 21, 2020·Physical Review. E·Konstantin V PiniginTimur R Galimzyanov
Feb 23, 2021·Frontiers in Microbiology·Inés RipaRaquel Bello-Morales

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