PMID: 9188658Jun 13, 1997Paper

Lateral meningocele syndrome: three new patients and review of the literature

American Journal of Medical Genetics
Karen W GrippE H Zackai

Abstract

One female and two male patients with multiple lateral meningoceles are presented. They do not have neurofibromatosis or Marfan syndrome and share findings with the two previously described patients with multiple lateral meningoceles. The original report by Lehman et al. [1977: J Pediatr 90:49-54] was titled "familial osteosclerosis," because osteosclerosis was present in the proposita and her mother; the patient described by Philip et al. [1995: Clin Dysmorphol 4:347-351] also had increased bone density of the skull base and the sutures. Thickened calvaria were present in one of our patients; two had a prominent metopic suture. Other shared findings include multiple lateral meningoceles, Wormian bones, malar hypoplasia, downslanted palpebral fissures, a high narrow palate, and cryptorchidism in males. In addition, our patients showed ligamentous laxity, keloid formation, hypotonia, and developmental delay. A short umbilical cord was noted in two patients. One had a hypoplastic posterior arch of the atlas and an enlarged sella, as reported by Lehman et al. [1977]. Our patients appear to have the same syndrome as previously reported. We suggest it be called "lateral meningocele syndrome," because of this unique finding.

Citations

Mar 9, 2010·Journal of Medical Case Reports·Afsoun Seddighi, Amir Saied Seddighi
May 12, 2011·Journal of Pediatric Neurosciences·Puneet K GoyalMonica Tandon
Apr 11, 2008·Taiwanese Journal of Obstetrics & Gynecology·Chih-Ping Chen
May 23, 2013·American Journal of Medical Genetics. Part a·Daniela AlvesMiguel Leão
Feb 7, 2015·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Marco CastoriPaola Grammatico
Jan 7, 2015·Saudi Journal of Biological Sciences·Gohar MushtaqMohammad A Kamal

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