PMID: 3746694May 1, 1986Paper

Lateral nasal gland secretion in the anaesthetized dog

The Journal of Physiology
U Wells, J G Widdicombe

Abstract

The effects of pharmacological and nervous stimuli on the flow of secretion from the dog lateral nasal gland following catheterization are described. Drugs were injected close-arterially into the arterial supply to the nose, or intravenously. Cholinergic agonists (pilocarpine, methacholine), given intravenously (I.V.) or intra-arterially (I.A.), and stimulation of the vidian nerve produced a copious flow of secretion which was blocked by atropine. The adrenoceptor agonists phenylephrine (alpha) and salbutamol (beta 2), given I.V. or I.A., and stimulation of the vagosympathetic nerve produced a small but consistent flow of secretion. Histamine (50 micrograms), substance P (0.1 micrograms) and prostaglandin E1 (1-5 micrograms), injected I.A., produced small flows of secretion. Bradykinin (25 ng-50 micrograms), 5-hydroxytryptamine (100 ng-50 micrograms) and vasoactive intestinal peptide (VIP) (10 ng-50 micrograms) did not cause secretion. The total protein content, the composition of secretions as revealed by sodium dodecyl sulphate-polyacrylamide agarose gel electrophoresis, and changes in [Na] and [K] in relation to flow of secretion are described. Differences in ion and protein concentrations, and in protein composition, are de...Continue Reading

Citations

Jul 1, 1994·Acta Physiologica Scandinavica·H SunoseA Nishiyama
May 13, 1999·Acta Oto-laryngologica·J S Lacroix, E K Potter
Nov 1, 1990·Respiratory Medicine·J G Widdicombe
Jun 13, 2008·The European Journal of Neuroscience·Nanaho FukudaKatsuhiko Mikoshiba
Feb 5, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alison May, Abigail Tucker
Jan 1, 1995·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·A C Chester
Mar 1, 1988·Cephalalgia : an International Journal of Headache·M FanciullacciF Sicuteri
Jan 1, 1988·Annals of the New York Academy of Sciences·F SundlerR Uddman
Sep 4, 2015·Physiological Reviews·Jonathan H Widdicombe, Jeffrey J Wine
Mar 1, 1988·British Journal of Pharmacology·P GeppettiF Sicuteri
May 16, 1998·Acta Oto-laryngologica·J S LacroixE McLachlan

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