Lateralization of the Subthalamic Nucleus with Age in Parkinson's Disease

Basal Ganglia
Julio L B PereiraNader Pouratian

Abstract

Age-related changes in subthalamic nucleus (STN) position have not been well characterized in patients with Parkinson's disease (PD). We report a systematic retrospective analysis of age-related changes in radiographic and final deep brain stimulator (DBS) STN coordinates in PD patients. The charts of 134 PD patients (97 males, 28-84 years) representing 255 STN were reviewed. Multiple linear regression, stepwise regression, and relative importance of regressors analysis was performed to determine the significance of the relationship between STN position and age. Across all subjects, both radiographic STN localization and final DBS position within the STN showed a lateralization of the STN target with age (R(2)=0.1096,p=6.9×10(-8) and R(2)=0.0433,p=8.7×10(-4), respectively). Lateralization with age was observed regardless of MR field strength (1.5T and 3.0T) (R(2)=0.0946,p=7.6×10(-6) and R(2)=0.2687,p=9.2×10(-5), respectively). No other consistent or clinically significant age-related changes were identified. Multiple linear regression revealed that the third ventricle width and age are statistically significant predictors of radiographic STN lateralization (R(2) = 0.2404, p = 1.51×10(-5) and p = .00784 respectively). Step-wise ...Continue Reading

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Citations

Jul 29, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Justin SharimNader Pouratian
Mar 3, 2018·Brain Topography·M C KeukenB U Forstmann
Oct 9, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Johannes Alexander KoeppenWolfgang Hamel
Aug 20, 2019·PloS One·Bethany R IsaacsMax C Keuken

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