Lateralized neuropsychological functioning in depressive patients before and after drug therapy

Biological Psychiatry
M H de GrootP F Bouvy

Abstract

Several decades of research have led to different hypotheses about cognitive functioning in depression; one of the hypotheses states that there is altered functioning of the hemispheres during a depressive episode. Lateralization studies have found diminished neuropsychological functioning in depressive patients; especially right-hemisphere functions seem impaired. In our study we used conventional neuropsychological tests to study shifts in hemispheric functioning. Neuropsychological testing before and after therapy in 52 (for the most part therapy-resistant) depressives showed no substantial effects in lateralized functioning. None of the measures enabled prediction of response to treatment; however 17 different interaction variables were identified, five of which make an unique contribution.

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Citations

Dec 13, 2006·Cognitive Neuropsychiatry·Denise LahrWolfgang Hartje
May 18, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Stefanie WagnerAndré Tadic
Aug 19, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Monique A PimontelJoel R Sneed
Dec 31, 2010·International Journal of Geriatric Psychiatry·Michelle E Culang-ReinliebJoel R Sneed
Sep 28, 2010·International Journal of Geriatric Psychiatry·Skye N McLennan, Jane L Mathias
Mar 24, 2000·The Psychiatric Clinics of North America·K M O'Leary
Apr 9, 2005·Journal of Clinical and Experimental Neuropsychology·Julie Henry, John R Crawford
Sep 14, 2018·Frontiers in Psychiatry·Samantha J GrovesRichard J Porter

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