Lateralizing Cortical Excitability in Drug Naïve Patients with Generalized or Focal Epilepsy

Journal of Epilepsy Research
Jung Hwa LeeSeung Bong Hong

Abstract

Numerous transcranial magnetic stimulation (TMS) studies have defined the characteristic features of TMS in epilepsy. TME parameters were expected to classify the epilepsy syndrome or drug responses. However, the results such as cortical silent periods (CSP) are variable according to conditions of patients. Here, we investigate whether specific TMS parameters have localizing or lateralizing values in drug-naïve epilepsy patients. We recruited 148 consecutive untreated patients with epilepsy (idiopathic generalized epilepsy (IGE) 38, focal epilepsy (FE) 110, mean age 31.4 years) and 38 age- and gender-matched normal subjects. We obtained resting motor threshold (RMT), motor-evoked potential (MEP), CSP, short interval intracortical inhibition (SICI, inter-stimuli interval 2-5 ms), and intracortical facilitation (ICF, inter-stimuli interval 10-20 ms). TMS were performed during a seizure-free state of more than 48 h. In IGE, no interhemispheric difference in CSP was found (p > 0.05). However, the mean CSP was longer in IGE patients than in normal controls at all stimulus intensities (p < 0.05). The mean CSP in ipsilateral hemisphere (IH) of FE was significantly longer at all stimulus intensities than that in normal controls (p < 0....Continue Reading

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Citations

Feb 18, 2020·Developmental Medicine and Child Neurology·Ann-Charlotte AndreassonTove Hallböök

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