Lateralizing value of memory tests in drug-resistant temporal lobe epilepsy

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L G GrammaldoG Di Gennaro

Abstract

Our aim was to test the lateralizing value of a neuropsychological battery including several memory tests on a large sample of consecutive patients with drug-resistant temporal lobe epilepsy (TLE) evaluated for epilepsy surgery. We studied 73 right-handed patients (56% males, mean age 35.3 +/- 11.2 years, 49% left TLE) aged 16 years or older with normal IQ who underwent a preoperative neuropsychological assessment including several memory tests and were seizure-free after at least 1 year of follow-up. Forty-seven had TLE due to hippocampal sclerosis, whilst 26 had TLE secondary to tumors or other lesions. Receiver Operating Characteristic (ROC) analysis and discriminant function analysis were used to evaluate the lateralization value of selected tests and of the battery as a whole, respectively. In patients with TLE secondary to tumors or other lesions, no test showed significant lateralizing value. In patients with TLE due to hippocampal sclerosis, the immediate (P < 0.01) and delayed (P < 0.001) Rey Auditory Verbal Learning Test (RAVLT) displayed substantial discriminatory ability. The battery as a whole correctly classified 82% of patients with respect to side of epileptogenesis. Our findings suggest that a non-invasive, rel...Continue Reading

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Citations

Nov 13, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Belgin KocerCeyla Irkec
Dec 6, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Brandon E Gavett, Julie E Horwitz
Nov 11, 2015·Seizure : the Journal of the British Epilepsy Association·Giancarlo Di GennaroAngelo Picardi
Oct 2, 2012·Neuropsychologia·Shannon M FosterDeana B Davalos
Aug 11, 2017·The International Journal of Neuroscience·Marco De RisiNicola Modugno
Dec 30, 2016·Brain and Behavior·Belgin KoçerRümeysa Çetinkaya
Dec 29, 2020·Neuropsychiatric Disease and Treatment·Langzi TanLili Long
Feb 18, 2021·Applied Neuropsychology. Adult·Sarah Barrett JonesSuncica Lah

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