Laterally extended endopelvic resection (LEER)--principles and practice

Gynecologic Oncology
Michael Höckel

Abstract

Exenteration has been used for the last 6 decades, mainly to treat cancers of the lower and middle female genital tract in the irradiated pelvis. New ablative techniques based on developmentally derived surgical anatomy termed laterally extended endopelvic resection (LEER) aim to increase the curative resection rate, even of tumors extending to and fixed to the pelvic side wall. LEER is performed as a combination of at least two of the following procedures: total mesorectal excision, total mesometrial resection, and total mesovesical resection. In cases of lateral tumor fixation, the inclusion of pelvic side wall and floor muscles, such as the obturator internus muscle and pubococcygeus, iliococcygeus and coccygeus muscles, and eventually of the internal iliac vessel system assures the completeness of the multicompartmental resection. One hundred patients with locally advanced (n=25) and recurrent (n=75) gynecologic tumors have been treated with these new procedures. In 76 patients, the tumors were fixed to the pelvic side wall. Two patients with advanced age and extensive comorbidity died during the early postoperative period. Moderate and severe treatment-related morbidity was 70%, mainly due to compromised healing of irradia...Continue Reading

References

May 13, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M Höckel

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Citations

May 27, 2014·Journal of Minimally Invasive Gynecology·Marcos BallesterEmile Daraï
Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Attibele Palaksha Manjunath, Shivarudraiah Girija
Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A E NobbenhuisD P J Barton
Feb 15, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·H SardainJ Levêque
Dec 24, 2015·The British Journal of Surgery·M J SolomonL Masya
Jan 17, 2012·Surgical Oncology·M PeirettiA Maggioni
May 15, 2010·Gynecologic Oncology·Charles Levenback
May 5, 2009·Gynecologic Oncology·Angelo MaggioniC Paul Morrow
Jul 15, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Yulia LakhmanEvis Sala
Aug 1, 2015·World Journal of Surgical Oncology·Kazuyoshi KatoMakio Shozu
Apr 30, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H SardainJ Levêque
Jan 29, 2013·Gynecologic Oncology·Kazuyoshi KatoMakio Shozu
Oct 22, 2011·Gynecologic Oncology·Fady Khoury-ColladoDennis S Chi
Jul 15, 2009·Gynecologic Oncology·Jeffrey M Fowler
Feb 6, 2014·The Cochrane Database of Systematic Reviews·Christine AngRaj Naik
Apr 9, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Elisa Moreno-PalaciosIgnacio Zapardiel
Feb 15, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Linda JägerAngelique Flöter Rådestad
Feb 27, 2019·La Radiologia medica·Martina SbarraRiccardo Manfredi
Jul 23, 2014·Current Opinion in Oncology·Manpreet KaurIgnace Vergote
Jan 1, 2010·Oncology Letters·Angiolo GadducciLuca Cionini
Jun 27, 2018·Chinese Medical Journal·Lei LiMing Wu
Jul 30, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Seiji MabuchiTadashi Kimura
Oct 27, 2018·The Cochrane Database of Systematic Reviews·Komsan ThamronganantasakulPisake Lumbiganon
Jan 31, 2021·Journal of Robotic Surgery·Vandana JainSudhir Rawal

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