Lathosterol-to-cholesterol ratio in serum predicts cholesterol-lowering response to plant sterol consumption in a dual-center, randomized, single-blind placebo-controlled trial

The American Journal of Clinical Nutrition
Dylan MackayPeter J H Jones

Abstract

Benefits of plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across individuals. High fractional cholesterol synthesis measured by deuterium incorporation has been associated with nonresponse to PS consumption; however, prospective studies that show this association have yet to be conducted. The goal was to test whether the lathosterol-to-cholesterol ratio (L:C ratio), a surrogate marker of endogenous cholesterol synthesis, serves as an a priori predictor of cholesterol lowering in response to PS consumption. Sixty-three mildly hypercholesterolemic adults who were preselected as possessing either high endogenous cholesterol synthesis [HS; n = 24; L:C = 2.03 ± 0.39 μmol/mmol (mean ± SD)] or low endogenous cholesterol synthesis (LS; n = 39; L:C = 0.99 ± 0.28 μmol/mmol) on the basis of baseline L:C consumed 2 g PS/d or a placebo for 28 d with the use of a dual-center, single-blind, randomized crossover design. Plasma lipid and noncholesterol sterol concentrations were measured at the end of each phase. PS consumption lowered total cholesterol (TC; -0.25 ± 0.05 mmol/L; P < 0.0001) and LDL cholesterol (-0.17 ± 0.04 mmol/L; P < 0.0001) overall. Specifically, LS individuals responded to PS t...Continue Reading

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Citations

Jan 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R T RasE A Trautwein
Aug 6, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Dylan S MackayPeter J H Jones
Nov 11, 2016·Critical Reviews in Food Science and Nutrition·Bianca ScolaroInar Alves de Castro
Aug 14, 2018·Nutrition Reviews·Peter J H JonesOliver Weingärtner
Sep 23, 2021·Molecular and Biochemical Parasitology·Rodrigo César Fernandes BarbosaValter Viana Andrade-Neto

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