Latifolin protects against myocardial infarction by alleviating myocardial inflammatory via the HIF-1α/NF-κB/IL-6 pathway.

Pharmaceutical Biology
Xiao-Xiao LaiRong-Hua Liu

Abstract

The Traditional Chinese herb medicine Dalbergia odorifera T. Chen (Fabaceae), exerted a protective effect on myocardial ischaemia. Latifolin is a neoflavonoid extracted from Dalbergia odorifera. It has been reported to have the effects of anti-inflammation and cardiomyocyte protection. To investigate whether latifolin can improve myocardial infarction (MI) through attenuating myocardial inflammatory and to explore its possible mechanisms. Left coronary artery was ligated to induce a rat model of MI, and the rats were treated with sodium carboxymethyl cellulose (CMC-Na) or different doses of latifolin (25, 50, 100 mg/kg/d) by oral gavage for 28 days. Serum contents of myocardial enzyme were measured at seven and fourteen days after treatment. Cardiac function, infarct size, histopathological changes and inflammatory cells infiltration was assessed at 28 days after treatment. Western blotting was used to investigate the underlying mechanisms. Latifolin treatment markedly decreased the contents of myocardial enzymes, and increased left ventricular ejection fraction (85.27% vs. 59.11%) and left ventricular fractional shortening (62.71% vs. 45.53%). Latifolin was found to significantly reduced infarction size (27.78% vs. 39.07%), my...Continue Reading

References

Oct 13, 2006·Antioxidants & Redox Signaling·Nikolaos G Frangogiannis
Jul 29, 2008·International Journal of Cardiology·Jessica M LambertMerry L Lindsey
Aug 7, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rena FeinmanDa-Zhong Xu
Jun 19, 2013·European Journal of Clinical Investigation·Panagiota Christia, Nikolaos G Frangogiannis
Mar 26, 2014·Nature Reviews. Cardiology·Nikolaos G Frangogiannis
May 8, 2014·Advances in Wound Care·Wan Xing HongMichael T Longaker
Aug 5, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Amit SaxenaNikolaos G Frangogiannis
Mar 5, 2016·Journal of the American College of Cardiology·Peter LibbyFilip K Swirski
Apr 14, 2016·Experimental and Therapeutic Medicine·Chunmei Xu, Weiguo Dong
Jun 25, 2016·Circulation Research·Sumanth D Prabhu, Nikolaos G Frangogiannis
Feb 9, 2017·Journal of Biomedical Science·Aleksandra GombozhapovaVyacheslav Ryabov
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 24, 2018·Journal of the American Heart Association·Xianwei WangJawahar L Mehta
Dec 28, 2018·Circulation·Yuan DaiJiang Chang
Jul 17, 2019·BMC Neuroscience·Robert H ThieleZhiyi Zuo
Mar 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Geng-Rui XuAi-Ying Li

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Methods Mentioned

BETA
coronary artery ligation
protein assay
electrophoresis

Software Mentioned

Image
Image J
Pro Plus
SPSS

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