Latitude has more significant impact on prevalence of multiple sclerosis than ultraviolet level or sunshine duration in Japanese population

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Masako KinoshitaMasami Tanaka

Abstract

Higher latitude is known to be associated with higher prevalence of multiple sclerosis (MS). We investigated the degree of impact of latitude, ultraviolet (UV) radiation, and sunshine on the prevalence of MS in Japan, which has 47 prefectures with a variety of climates. MS prevalence in each prefecture was collected from database of the Ministry of Health, Labour, and Welfare of Japan. Latitude of each prefecture was represented by that of the capital city. Data of UV radiation level and annual actual sunshine duration were obtained from databases of Japan Meteorological Agency. We performed linear correlation analyses of MS prevalence against latitude, UV radiation, and annual actual sunshine duration. MS prevalence significantly correlated to latitude (Pearson's correlation, r = 0.69, p < 0.001) and UV radiation level (r = -0.65, p < 0.001) but not to annual actual sunshine duration (r = -0.37, p = 0.011). Stepwise multiple linear regression analyses revealed significant correlation between MS prevalence and only latitude (p < 0.001). While our result shows that both latitude and the UV intensity have significant relationship to MS prevalence, the stronger relevance of the former suggests an existence of risk factors other th...Continue Reading

References

Feb 1, 1988·Brain : a Journal of Neurology·S R HammondM G McCall
Mar 3, 1999·American Journal of Human Genetics·T M KarafetM F Hammer
Aug 9, 2003·BMJ : British Medical Journal·I A F van der MeiT Kilpatrick
Mar 5, 2004·Journal of Human Genetics·Atsushi TajimaSatoshi Horai
Dec 6, 2005·Journal of Human Genetics·Michael F HammerSatoshi Horai
Feb 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Sandra VukusicChristian Confavreux
Apr 19, 2007·Brain : a Journal of Neurology·Takeshi MatsuokaJun-ichi Kira
Apr 3, 2008·Neuroepidemiology·Margitta T Kampman, Magritt Brustad
Nov 7, 2008·Multiple Sclerosis : Clinical and Laboratory Research·M OsoegawaUNKNOWN Research Committee of Neuroimmunological Diseases
Sep 4, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Bruce V TaylorClive Sabel
Apr 12, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Steve SimpsonBruce Taylor
May 10, 2011·Multiple Sclerosis : Clinical and Laboratory Research·J RiscoD Vizcarra
Dec 22, 2011·Multiple Sclerosis : Clinical and Laboratory Research·J Lechner-ScottUNKNOWN MSBase study group
Sep 22, 2012·Journal of the Neurological Sciences·Hideki HouzenHidenao Sasaki

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Hideyuki MotohashiYoshitaka Yano
Rinsho byori. The Japanese journal of clinical pathology
Nobuko KannoYutaka Yatomi
Journal of Neurology, Neurosurgery, and Psychiatry
Bruce V Taylor
© 2022 Meta ULC. All rights reserved