Laughter counteracts enhancement of plasma neurotrophin levels and allergic skin wheal responses by mobile phone-mediated stress

Behavioral Medicine
Hajime Kimata

Abstract

Laughter caused by viewing a comic video (Rowan Atkinson's The Best Bits of Mr. Bean) reduced the plasma nerve growth factor, neurotrophin-3 levels, and allergic skin wheal responses in patients with atopic dermatitis, whereas viewing a nonhumorous video (weather information) failed to do so. In contrast, stress induced by writing mail on a mobile phone enhanced the plasma nerve growth factor, neurotrophin-3 levels, and allergic skin wheal responses. However, previewing the comic video counteracted mobile phone-mediated enhancement of plasma neurotrophins or allergic skin wheal responses, whereas previewing the weather information failed to do so. Taken together, these results suggest that, in patients with atopic dermatitis, writing mail on a mobile phone causes stress and enhances allergic responses with a concomitant increase in plasma neurotrophins that are counteracted by laughter. These results may be useful in the study of pathophysiology and treatment of atopic dermatitis.

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Citations

Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Margaret StuberLonnie Zeltzer
May 19, 2007·Biomedical Research·Masahiro TodaKanehisa Morimoto
Aug 29, 2014·Electromagnetic Biology and Medicine·Sibel TürediErsan Odacı
Nov 19, 2010·The Journal of Investigative Dermatology·Eva M J PetersBurghard F Klapp
Jun 2, 2007·Journal of Psychosomatic Research·Hajime Kimata
Jun 23, 2009·European Journal of Gastroenterology & Hepatology·Hajime Kimata
Nov 11, 2009·Holistic Nursing Practice·Julia Wilkins, Amy Janel Eisenbraun
Feb 13, 2018·Immunological Reviews·Martin K ChurchMarcus Maurer

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.