Abstract
Laughter caused by viewing a comic video (Rowan Atkinson's The Best Bits of Mr. Bean) reduced the plasma nerve growth factor, neurotrophin-3 levels, and allergic skin wheal responses in patients with atopic dermatitis, whereas viewing a nonhumorous video (weather information) failed to do so. In contrast, stress induced by writing mail on a mobile phone enhanced the plasma nerve growth factor, neurotrophin-3 levels, and allergic skin wheal responses. However, previewing the comic video counteracted mobile phone-mediated enhancement of plasma neurotrophins or allergic skin wheal responses, whereas previewing the weather information failed to do so. Taken together, these results suggest that, in patients with atopic dermatitis, writing mail on a mobile phone causes stress and enhances allergic responses with a concomitant increase in plasma neurotrophins that are counteracted by laughter. These results may be useful in the study of pathophysiology and treatment of atopic dermatitis.
References
Mar 1, 1992·Brain Research. Molecular Brain Research·N RocamoraG Mengod
Oct 1, 1992·European Journal of Clinical Investigation·I C ChikanzaG S Panayi
Mar 1, 1986·The Journal of Physiology·F L Pearce, H L Thompson
Apr 1, 1989·Agents and Actions·M al-Laith, F L Pearce
Dec 1, 1984·Journal of Behavior Therapy and Experimental Psychiatry·J Wolpe
Mar 1, 1995·The Journal of Allergy and Clinical Immunology·J H PersoonsG Kraal
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L AloeP Tirassa
Jun 18, 1998·Annals of the New York Academy of Sciences·A Buske-KirschbaumD H Hellhammer
Dec 14, 1999·European Journal of Pediatrics·H Kimata
Feb 15, 2001·JAMA : the Journal of the American Medical Association·H Kimata
Dec 12, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O NogaG Kunkel
Mar 6, 2002·Blood·Hitoshi KobayashiHirohito Kita
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KilpeläinenE O Terho
Jul 9, 2002·The British Journal of Dermatology·M ToyodaM Morohashi
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Angelika Buske-KirschbaumDirk Hellhammer
Apr 5, 2003·Brain, Behavior, and Immunity·Hajime Kimata
Feb 24, 2004·Behavioral Medicine·Hajime Kimata
Citations
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Margaret StuberLonnie Zeltzer
May 19, 2007·Biomedical Research·Masahiro TodaKanehisa Morimoto
Aug 29, 2014·Electromagnetic Biology and Medicine·Sibel TürediErsan Odacı
Feb 13, 2008·The Journal of Sexual Medicine·Hajime Kimata
Jan 22, 2009·Journal of Psychosomatic Research·Hajime Kimata
Nov 19, 2010·The Journal of Investigative Dermatology·Eva M J PetersBurghard F Klapp
Aug 19, 2007·International Journal of Hygiene and Environmental Health·James R Jauchem
Jun 2, 2007·Journal of Psychosomatic Research·Hajime Kimata
Jul 4, 2006·Journal of Psychosomatic Research·Hajime Kimata
Jun 23, 2009·European Journal of Gastroenterology & Hepatology·Hajime Kimata
Nov 11, 2009·Holistic Nursing Practice·Julia Wilkins, Amy Janel Eisenbraun
Jul 8, 2018·BMJ Open·Yurika ImaiKatsunori Kondo
Feb 13, 2018·Immunological Reviews·Martin K ChurchMarcus Maurer
Jan 9, 2021·BMJ Open·Masato NagaiKatsunori Kondo