Laughter up-regulates the genes related to NK cell activity in diabetes

Biomedical Research
Takashi HayashiKazuo Murakami

Abstract

To elucidate the sustainable effects of laughter on gene expression, we recruited type 2 diabetic patients who were in-patient for receiving self-management education and examined time-dependent regulation for gene expression by laughter. Two-day experiment was performed. On one day, the patients watched comic video and laughed together with hospital staffs. On the other day, they participated in an inpatient diabetes educational program. Blood samples were collected before and 1.5, 4 h after watching comic video or spending lecture time, and changes in gene expression were comprehensively analyzed by microarray technique. Of the 41,000 genes analyzed, the laughter relatively up-regulated 39 genes, among which, 27 genes were relatively increased in the expression for all the observation period after watching comic video. By functional classification of these genes, 14 genes were found to be related to natural killer cell activity. No genes were included that are directly involved in blood glucose regulation, though successive suppression of postprandial blood glucose levels was observed. These results suggest that the laughter influences the expression of many genes classified into immune responses, and may contribute to amelio...Continue Reading

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Citations

Mar 31, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Paweł Piątkiewicz, Anna Czech
Jul 14, 2010·BMC Biology·Damien ChaussabelJacques Banchereau
Dec 16, 2010·International Immunopharmacology·Fuminori AbeJames E Talmadge
Oct 27, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Kyung Hee RyuEun Young Yang
Jan 29, 2014·Seminars in Dialysis·Paul N BennettAlison Hutchinson
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Jul 22, 2016·The Tohoku Journal of Experimental Medicine·JongEun Yim
Dec 3, 2016·Hospital Pediatrics·Julio C SánchezJoaquín O Ruiz

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