Lawsone-loaded Niosome and its antitumor activity in MCF-7 breast Cancer cell line: a Nano-herbal treatment for Cancer

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Mahmood BaraniMohammad Hadi Nematollahi

Abstract

Phytochemicals like Lawsone have some drawbacks that stem from their poor solubility. Low solubility in aqueous mediums results in low bioavailability, poor permeability and instability of phytochemical compounds in biological environments. The aim of this study was to design nanoniosomes containing Lawsone (Law) using non-ionic surfactants and cholesterol. Niosomes were prepared by thin film hydration method (TFH). Then, they were loaded with Henna extract (HLaw) and standard Lawsone (SLaw), and two resulted formulations were compared. The henna extract was analyzed by mass gas chromatography. Size, zeta potential, polydispersity index (PDI) and morphology of the loaded formulations were evaluated by dynamic light scattering (DLS) and scanning electron spectroscopy (SEM). The incorporation and release rate of Law from niosome bilayers were evaluated by UV-Vis spectroscopy. In vitro experiments were carried out to evaluate antitumor activity in MCF-7 cell line. The results showed distinct spherical shapes and particle sizes were about 250 nm in diameter and have negative zeta potentials. Niosomes were stable at 4 °C for 2 months. Entrapment efficiently of both formulations was about 70% and showed a sustained release profile. I...Continue Reading

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Citations

May 28, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohammad Reza HajizadehMasoud Torkzadeh-Mahani
Aug 19, 2020·Drug Development and Industrial Pharmacy·Iman AkbarzadehHaleh Bakhshandeh
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Apr 24, 2019·Nanomaterials·Beatriz García-PinelJuan M López-Romero
Sep 3, 2020·Nanomaterials·Mahmood BaraniGeorge Z Kyzas
Dec 20, 2020·Life Sciences·Mahmood BaraniGeorge Z Kyzas
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Apr 4, 2021·International Journal of Molecular Sciences·Seyedeh Maryam HosseinikhahMagali Cucchiarini
Nov 3, 2020·Biochemical and Biophysical Research Communications·Gholamreza AsadikaramMohammad Hadi Nematollahi
Jun 3, 2021·Cancers·Mahmood BaraniSadanand Pandey
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Methods Mentioned

BETA
scanning electron spectroscopy
transmission electron microscopy

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